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Brian Wilcox, MD, PhD

Associate Professor of OB-GYN
Department of Medical Education
North Campus

LOCATION(S)
Geisinger Commonwealth School of Medicine
Medical Sciences Building
525 Pine St.
Office 3047
Scranton, PA 18509
570-558-4252
Fax: 570-504-9663
bwilcox@som.geisinger.edu

Biography

Brian D. Wilcox, MD, PhD, is an associate professor of obstetrics and gynecology. He is also a part-time practicing obstetrician/gynecologist in Scranton and Clarks Summit, Pa. He holds a PhD degree in physiology and cell biology from Cornell University and an MD degree from Albany Medical College in Albany, New York. His research interests involve complications of pregnancy including mechanisms that underlie labor, preterm labor and recurrent pregnancy loss.

Recent publications

  • Radin,R.S., Mumford,S.L., Sjaarda,L.A., Silver,R.M.,Wactawski-Wende,J., Lynch, A.M., ; Perkins, N.J.,Lesher,L.L., Wilcox,B.D., ; Hinkle, S.N., Plowden,T.C., Kim, K., Schisterman, E.F. (2017) Recent attempted and actual weight change in relation to pregnancy loss (Accepted, In Press: BJOG)
  • Sjaarda LA, Radin RG, Silver RM, Mitchell E, Mumford SL, Wilcox B, Galai N, Perkins NJ, Wactawski-Wende J, Stanford JB, Schisterman EF. Preconception low-dose aspirin restores diminished pregnancy and live birth rates in women with low grade inflammation: a secondary analysis of a randomized trial. J Clin Endocrinol Metab. 2017, 102(5), 1495
  • Pugh, S.J., Schisterman, E.F., Browne, R.W., Lynch, A.M., Mumford, S.L., Perkins, N.J., Silver, R., Sjaarda, L., Stanford, J., Wactawski-Wende, J. Wilcox, B., and Grnatz, K.L. (2016) Preconception maternal lipoprotein levels in relation to fertility and time to pregnancy. Hum Reprod. 2017, 32(5), 1055.
  • Melendez, J. A., Vinci, J. M., Jeffrey, J. J. and Wilcox, B. D. (2001) Localization and regulation of interleukin-1a in the rat myometrium during late pregnancy and the postpartum period. Am. J. Physiol.280: R879-R888.
  • Wilcox, C. B., Weisberg, E., Dumin, J. A., Wilcox, B. D. and Jeffrey, J. J. ( 2000) Serotonin-Dependent Collagenase Transcription Requires an Extended AP-1 Site. Molec. Cell. Endocrinol,. 170, 41-56.
  • Richard, C. A. H., Wilcox, B. D. and Loegering, D. J. (2000) IgG-coated erythrocytes augment LPS-stimulated TNF-a secretion, TNF-a mRNA levels, and TNF-a mRNA stability in macrophages. Biochem. Biophys. Res. Com., 271, 70-74.
  • Lan, L., Vinci, J. M., Melendez, J. A. Jeffrey, J. J. and Wilcox, B.D. (1999) Progesterone mediates decreases in uterine smooth muscle cell interleukin-1a by a mechanism involving decreased stability of IL-1a mRNA. Molec. Cell. Endocrinol, 155:1, pp. 123-133.
  • Huang, T.T., Vinci, J. M., Lan, L., Jeffrey, J. J. & Wilcox, B. D. (1999) Serotonin-inducible transcription of interleukin-1a in uterine smooth muscle cells: cloning and characterization of the rat IL-1a promoter. Molec. Cell. Endocrinol, 152:1, pp. 21-35.
  • Dumin, J. A., Wilcox, B. D., Otterness, I., Melendez, J. A., Huang, C. and Jeffrey, J. J. (1998) Serotonin-mediated production of interstital collagenase by uterine smooth muscle cells requires interleukin-1a but not interleukin -1b. J. Biol. Chem. 273, 25488-25494
  • Lin, H.-Y., Martino, L. J., Wilcox, B. D., Davis, F. B., Gordinier, J. K. and Davis, P. J. (1998) Potentiation by thyroid hormone of human interferon-g-induced HLA-DR expression. J. Immunology, 161, 843-849.
  • Passaretti, T.V., Wilcox, B.D., and Jeffrey, J.J., (1996) Serotonin regulation of gene expression in uterine extracellular matrix: reciprocal effects on collagens and collagenase. Molec. Cell. Endocrinol, 120, 125-132.
  • Du, Y.L., Wilcox, B.D., and Jeffrey, J.J. (1995) Regulation of rat 5-hydroxytryptamine type 2 receptor gene activity: identification of cis-elements which mediate basal and 5-hydroxytryptamine-dependent gene activation. I. 47, 915-922.
  • Wilcox, B.D., Dumin, J.A., and Jeffrey, J.J. (1994) Serotonin regulation of interleukin-1 messenger RNA in rat uterine smooth muscle cells: relationship to the production of interstitial collagenase. J. Biol. Chem, 269, 29658-29664.
  • Wilcox, B.D., Rydelek-Fitzgerald, L., and Jeffrey, J.J. (1994) Regulation of uterine collagenase gene expression: interactions between serotonin and progesterone. Molec. Cell. Endocrinol. 101, 76-75.
  • Du, Y.L., Wilcox, B.D., Teitler, M. and Jeffrey, J.J. (1994) Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter: constitutive and inducible activity in myometrial smooth muscle cells. Molec. Pharmacol. 45, 1125-1131.
  • Deecher, D.C., Wilcox, B.D., Dave, V., Rossman, P.A. and Kimmelberg, H.K. (1993) Detection of 5-hydroxytryptamine2 receptors by radioligand binding, northern blot analysis, and Ca2+ responses in rat primary astrocyte cultures. J. Neurosci. Res. 35, 246-256.
  • Rydelek-Fitzgerald, L., Wilcox, B.D., Teitler, M. and Jeffrey, J.J. (1993) Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells. Molec. Cell. Endocrinol. 92, 253-259.
  • Rydelek-Fitzgerald, L., Wilcox, B.D., Teitler, M. and Jeffrey, J.J. (1993) Serotonin-dependent collagenase induction in rat myometrial smooth muscle cells: mediation by the 5-HT2 receptor. Molec. Cell. Endocrinol. 91, 67-74.
  • Wilcox, B.D., Rydelek-Fitzgerald, L., and Jeffrey, J.J. (1992) Regulation of collagenase gene expression by serotonin and progesterone in rat uterine smooth muscle cells. J. Biol. Chem. 267, 20752-20757.

Abstracts (oral or poster presentations)

  • Mumford SL, Kim K, Browne RW, Sjaarda LA, Connell MT, Omosigho UR, Kuhr DL, Wilcox BD, Silver RM, Perkins NJ, Holland T, Schisterman EF  Plasma fatty acids and ovulation in women with proven fecundidty  (2017) American Society for Reproductive Medicine, October, 2017
  • Plowden TC, Connell MT, Mendola P, Kim K, Nobles C, Wilcox B, Kuhr DL, Galai N, Gibbins K, Silver RM, Schisterman EF, Mumford SL  (2017) Association of a family history of autoimmune disease with time to pregnancy, pregnancy loss, and live birth rate. American Society for Reproductive Medicine, October, 2017
  • Wilcox BD, Iobst W, Bremer  D, Williams C, Townsend J, Cornacchione M, Shoemaker M, and Callender D, (2016) Improving Students' Perception of Inpatient Learning Experiences: Transitioning from a 12-Month to a 6-Month LIC, Consortium on Longitudinal Integrated Clerkships, Toronto,  October, 2016
  • Cornacchione M, Callender D, Shoemaker M, and Wilcox BD (2016) Ensuring and Evaluating the Delivery of Core Family Medicine and Geriatric Medicine Content in a Shortened Family Medicine LIC Experience. Consortium on Longitudinal Integrated Clerkships, Toronto,  October, 2016
  • Dunleavy E, Callender D, Townsend J, Williams C, Iobst W, DiMattia A, and Wilcox BD, Student Perceptions of Confidence and Skill Level After Completion of Block or LIC Experiences.  Consortium on Longitudinal Integrated Clerkships, Toronto,  October, 2016
  • Shoemaker,M., Callender,D., Wilcox,B.D., Chandragiri,S. Successful Incorporation of Mid-Level Instructors in a Psychiatry and OB/Gyn LIC,  Consortium on Longitudinal Integrated Clerkships, Toronto,  October, 2016
  • Sjaarda LA, Radin R, Perkins NJ, Silver R, Stanford J, Wactawski-Wende J, Galai N, Wilcox B, Schisterman EF (2016).  Preconception aspirin improves live birth rates in lean, but not overweight-obese, women with higher inflammation. Epidemiology Congress of the Americas,  Society for Epidemiologic Research, Miami, FL, July, 2016 
  • L Sjaarda, R Radin, R Silver, E Mitchell , S Mumford , B Wilcox, N Galai , N Perkins, J Wactawski-Wende, J Stanford , E Schisterman .  (2016) Effect of preconception-initiated low dose aspirin therapy on C-reactive protein throughout pregnancy: the EAGeR Trial. Society for Pediatric and Perinatal Epidemiologic Research, Miami, FL, June 2016.
  • Pugh SJ, Schisterman EF, Perkins N, Mumford S, Sjaarda L, Browne RW, Silver R, Wactawski-Wende J, Galai N, Stanford J, Wilcox B, Lynch A, Grantz KL. (2016) Maternal Lipids and Time to Pregnancy. Society for Pediatric and Perinatal Epidemiologic Research, Miami, FL, June 2016.
  • Kim K, Schisterman EF, Browne RW, Silver RM, Stanford JB, Sjaarda LA, Perkins NJ, Galai N, Wilcox BD, Lesher LL, Mumford SL (2016)Fat Soluble Micronutrients and Time To Pregnancy, Society for Pediatric and Perinatal Epidemiologic Research, Miami, FL, June 2016 
  • Callender, D. Townsend, J. Averill, D. Wilcox, B. Perlis, S. Clifton, M. and Weber, V (2015)  Outcomes of Implementing a Longitudinal Integrated Clerkship for all Third year Students at a New Allopathic Medical School. Proceedings of the annual meeting of the  InternationalAssociation of Medical Science Educators (IAMSE).  
  • Shoemaker, M., Callender, D., Shetty, S., Wilcox, B., Williams, C., & Townsend, J., (2015)  Logistical Dilemmas Associated With Increasing Class Size in a 12-Month Longitudinal Integrated Clerkship Model.  Consortium on Longitudinal Integrated Clerkships, Ashville, NC,  October, 2015
  • Arruda-Musser, K. Herrick-Davis, K., Grinde, E., Teitler, M., Wilcox, B. D. and Jeffrey, J. J.  (1999)  Serotonin 5-HT2a receptor mRNA alternative splicing and translational modulation. Soc. Neurosci. Abstr. 25,  pt 1, 1165.
  • Buddenhagen, C. A. Wilcox, B. D. and Jeffrey, J. J. (1998)  Serotonin-induction of the collagenase promoter in uterine smooth muscle cells depends on an AP-1 site and an adjacent extended palindrome.  Specificity in Signal Transduction, Keystone Symposia on Molecular and Cellular Biology.  
  • Arruda-Musser, K. Wilcox, B. D. and Jeffrey, J. J.  (1998)  Translational control mechanisms utilized by the serotonin 5HT2a receptor gene.  Experimental Biology, 1998.  FASEB.
  • Melendez, J. A. and Wilcox, B. D. (1997)  Localization and regulation of uterine interleukin-1[Symbol] during normal pregnancy and delivery. Molec. Biol. Cell (Suppl.) 8: p. 317a
  • Lan, L. and Wilcox, B. D. (1997)  Progesterone-mediated post-transcriptional regulation of interleukin-1[Symbol] mRNA in uterine smooth muscle cells. Molec. Biol. Cell (Suppl.) 8: p 315a. 
  • Sanchez, J. L., Wilcox, B. D.  and Jeffrey, J. J. (1997)  Differential regulation of matrix metalloproteinase gene expression by serotonin and progesterone in rat uterine smooth muscle cells.  J. Amer. Ped. Soc. (1997)
  • Dumin, J.A., Wilcox, B.D. and Jeffrey, J.J. (1995) Serotonin-mediated production of interleukin-6 by myometrial smooth muscle cells.  Molec. Biol. Cell (Suppl.) 6: p. 16a.
  • Dumin, J.A., Wilcox, B.D. and Jeffrey, J.J. (1994) Serotonin-induced interleukin-1[Symbol] is required for the production of collagenase in uterine smooth muscle cells.  The Physiologist. 37, A-48.
  • Du, Y.-L., Wilcox, B.D. and Jeffrey, J.J. (1993) Characterization of the rat 5HT2 receptor promoter: 5HT2 receptor-mediated activation.  In: Mechanisms for Cell Growth and Differentiation.  Proceedings of the 46th Annual Symposium on Fundamental Cancer Research, U. of Texas, MD Anderson Cancer Center, p. 99.
  • Leonhardt, S., Herrick-Davis, K., Wilcox, B.D., Hoffmann, B.J. and Teitler, M.  (1993) Site-specific mutagenesis demonstrates that arginine 195 in TMD4 is a critical determinant for agonist affinities at the 5-HT1c and 5-HT2 receptors.  Soc. Neurosci. Abstr. 19,  pt 2, 1165.
  • Wilcox, B.D., Rydelek-Fitzgerald, F., Gray, V.C. and Jeffrey, J.J. (1991) Transcriptional regulation of rat uterine smooth muscle cell collagenase by serotonin and progesterone.  J. Cell Biol., 115: 3, pt 2,  139. 
  • Rydelek-Fitzgerald, L., Wilcox, B.D., Teitler, M. and Jeffrey, J.J. (1991) Serotonin-mediated regulation of collagenase production and 5-HT2 receptor mRNA in rat uterine smooth muscle cells. J. Cell Biol., 115: 3, pt 2, 139
  • Rydelek-Fitzgerald, L., Wilcox, B.D., Teitler, M. and Jeffrey, J.J. (1991) Comparison of the molecular regulation and pharmacology of 5-HT2 receptors in brain and smooth muscle cells.  Soc. Neurosci. Abstr. 17, 408. 
  • Wilcox, B.D., Ignotz, G.G. and Currie, W.B. (1988). Effects of ovariectomy, steroid replacement and parturition on the concentration and specific activity of creatine kinase in the myometrium and endometrium of the pregnant rabbit. Journal of Reproduction and Fertility Abstract Series, 1, 79. 
  • Wallace, C.R., Michell, F.J., Wilcox, B.D. and Currie, W.B. (1987). Tissue binding of bovine placental lactogen in pregnant and non-pregnant cows. Journal of Animal Science, 65: (Suppl.1), 414.
  • Yang, X., Simkin, M., Battista, M., Wilcox, B., and Foote, R.H. (1986). Asychronous embryo transfer in rabbits.  Theriogenology, 25, 219.

 

Education

BS with honors and distinction in animal science – Cornell University, Ithaca, New York
PhD in physiology and cell biology – Cornell University, Ithaca, New York
MD with honors – Albany Medical College, Albany, New York 
Internship, obstetrics and gynecology – Albany Medical Center Hospital,  Albany, New York
Residency, obstetrics and gynecology – Magee-Women’s Hospital, University of Pittsburgh Medical Center