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Christian Carbe

Assistant Professor of Medical and Molecular Genetics and Immunology
Department of Medical Education
North Campus
Doylestown Campus

LOCATION(S)
Geisinger Commonwealth School of Medicine
Medical Sciences Building
525 Pine St.
Office 3024
Scranton, PA 18509
570-558-4257
ccarbe@som.geisinger.edu

Research interests

Murine developmental genetics involving signal transduction pathways during mammalian eye development, cell mediated-immunity and immunological tolerance checkpoint mechanisms regulated by follicular helper T cell:B cell interactions at the murine germinal center, the functional roles that steroid hormone receptors play in human endocrine-related cancers 

Educational interests

Participating in interdisciplinary biomedical courses in MBS-Doylestown and MBS-Scranton programs that include lectures in the areas of genetics, immunology, cell biology, physiology, neuroscience and seminars in the biomedical sciences, Facilitating MD1 small groups for CBL-1

Recent publications

  • Carbe C, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA. 2014. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. American Journal of Physiology, Heart and Circulatory Physiology. 307(1):H66-72.
  • Carbe C, Garg A, Cai Z, Li H, Powers A, Zhang X. 2013. An Allelic Series at the Pax6 Locus Reveals the Functional Specificity of Pax Genes. Journal of Biological Chemistry. 288:12130-12141.
  • Carbe C, Hertzler-Schaefer K, Zhang X. 2012. The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Developmental Biology. 363(1):320-9.
  • Carbe C and Zhang X. 2011. Lens induction requires attenuation of ERK signaling by Nf1. Human Molecular Genetics. 20(7):1315–1323.
  • Qu X, Carbe C (co-first author), Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X. 2011. Lacrimal gland development and Fgf10-Fgfr2b signaling is controlled by 2-O and 6-O sulfated heparan sulfate. Journal of Biological Chemistry. 286(16):14435-14444. Rated at the top 2% of published articles in biology and medicine by the Faculty of 1000 (F1000).
  • Pan Y, Carbe C, (co-first author), Powers A, Feng GS, Zhang X. Sprouty2 modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development (2010) 137:1085-1093.
  • Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng G-S, Zhang X. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development (2008) 135(2):301-10.
  • Pan Y, Carbe C, Kupich S, Pickhinkle U, Ohlig S, Frye M, Seelige R, Palleria SR, Moon AM, Lawrence R, Esko JD, Zhang X, Grobe K. Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis. Matrix Biol. (2014) Apr;35:253-65.
  • Qu X, Pan Y, Carbe C, Powers A, Grobe K, Zhang X. Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development (2012) Jun 28 [Epub ahead of print].

Education

PhD in Medical and Molecular Genetics and Minor in Biochemistry, 2011 – Indiana University School of Medicine, Indianapolis, IN

Postdoctoral Research Fellow – Thomas Jefferson University, Department of Biochemistry and Molecular Biology, Philadelphia, PA: Biochemical and cell-based investigation into the functional roles that Hedgehog (Hh) (GPCR) signal transduction pathways play in key mammalian cellular processes including proliferation, apoptosis and cell migration

Postdoctoral Research Fellow – Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, PA): Immunological investigation of the roles Follicular helper CD4 T cells (TFH) play during B cell autoimmunity

Postdoctoral Researcher with Dr. Raj Kumar – Geisinger Commonwealth School of Medicine, Scranton, PA. (April, 2015 – September, 2016): Investigated the role of novel steroid hormone receptor-based therapeutics for endocrine-related triple negative breast cancers (TNBCs)