William Kinney, PhD, is a medicinal chemist and entrepreneur with greater than 25 years of experience in large pharmaceutical (Wyeth, Johnson & Johnson), biotechnology (Magainin) and non-profit (Blumberg Institute) research and development. He has demonstrated expertise in drug design; synthesis; lead optimization of peptides, small molecules and natural products; and is inventor of three molecules that advanced to human clinical trials – Perzinfotel (CNS disorders and pain), Squalamine (oncology and AMD) and Trodusquemine (obesity). In 2000, he joined Johnson & Johnson, where he pursued peptide-mimetic integrin antagonists and urotensin-II receptor modulators for cardiovascular indications. He also made seminal discoveries with respect to self-assembling collagen-mimetic peptides that stimulate platelet aggregation.
Currently, Dr. Kinney is a faculty member within the Baruch S. Blumberg Institute (BSBI) and facilitates projects within the Natural Product Discovery Institute (NPDI). He is an adjunct faculty member at Drexel University and founder of IteraMed, a company focused on medicinal chemistry, drug discovery and small business development. Dr. Kinney is chief scientific officer at Kannalife Sciences and leads the chemistry optimization and scale-up of KLS-13019. His scientific contributions include 70 publications, invited lectures, oral presentations and inventorship on 41 issued U.S. patents. Four relevant publications in natural product optimization, isolation, synthesis and mimicry are shown here.
- “Discovery of KLS-13019, a cannabidiol-derived neuroprotective agent, with improved potency, safety, and permeability” W. A. Kinney, M. E. McDonnell, H. M. Zhong, C. Liu, L. Yang, W. Ling, T. Qian, Y. Chen, Z. Cai, D. Petkanas, D. E. Brenneman, ACS Med. Chem. Lett. 2016, Article ASAP.
- “Aminosterols from the Dogfish Shark Squalus acanthias” M. R. Rao, A. E. Shinnar, L. A. Noecker, T. L. Chao, B. Feibush, B. Snyder, I. Sharkansky, A. Sarkahian, X. Zhang, S. R. Jones, W. A. Kinney, M. Zasloff, J. Nat. Products 2000, 63 (5), 631-635.
- “Synthesis of Squalamine Utilizing a Readily Accessible Spermidine Equivalent” X. Zhang, M. N. Rao, S. R. Jones, B. Shao, P. Feibush, M. McGuigan, N. Tzodikov, B. Feibush, I. Sharkansky, B. Snyder, L. M. Mallis, A. Sarkahian, S. Wilder, J. E. Turse, W. A. Kinney, H. J. Kjaersgaard, R. S. Michalak, J. Org. Chem. 1998, 63, 8599-8603.
- “Thrombogenic Collagen-Mimetic Peptides: Self-Assembly of Triple Helix-Based Fibrils Driven by Hydrophobic Interactions” M. A. Cejas, W. A. Kinney, C. Chen, J. G. Vinter, H. R. Almond, Jr., K. M. Balss, C. A. Maryanoff, U. Schmidt, M. Breslav, A.Mahan, E. Lacy, C. Yang, B. E. Maryanoff, Natl. Acad. Sci. USA 2008, 105, 8525-8530.
BS 1979, PhD 1984 – Ohio State University