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Aejaz Sayeed

Assistant Professor, Baruch S. Blumberg Institute
Adjunct Assistant Professor Biochemistry, Geisinger Commonwealth School of Medicine
Department of Medical Education
Doylestown Campus

LOCATION(S)
Geisinger Commonwealth School of Medicine
Doylestown Campus
Pennsylvania Biotechnology Center of Bucks County
3805 Old Easton Road
Office 127
Doylestown, PA 18902
215-589-6350
asayeed@som.geisinger.edu

Biography

Aejaz Sayeed, PhD, is a molecular cell biologist with a particular focus on cancer biomarkers associated with the entire spectrum of the disease. His research interests are focused on the mechanisms of cancer progression and development of refractory states with a special emphasis on cellular signaling, metabolism, targeted therapeutics and microvesicles.

Before joining Baruch S. Blumberg Institute as an assistant professor, Dr. Sayeed worked as a research faculty for more than six years in the department of cancer biology at Thomas Jefferson University where he studied the molecular crosstalk between β1 integrins and insulin-like growth factor receptor. He received an American Cancer Society/IRG award for this work. Using in vivo conditional transgenic model systems of prostate cancer, Dr. Aejaz investigated underlying molecular mechanisms of radiation resistance and also dissected the role of exosomes in prostate cancer progression. At Thomas Jefferson University, he taught courses on cancer signaling and metabolism in the graduate program of biochemistry and molecular biology.

Dr. Sayeed  worked as a research associate scientist at California Pacific Medical Center in San Francisco, where he specialized in creating a battery of primary breast cancer cell lines representing all histologic grades of the disease and investigated genetic signatures associated with cancer aggressiveness in an effort to discover and characterize novel molecular markers of aggressive disease. While working in Roswell Park Cancer Institute’s Department of Pharmacology and Therapeutics, Dr. Sayeed  conducted a pioneering study in establishing the molecular interaction between tumor suppressor p53 and estrogen receptor in breast cancer which explained the compromised tumor suppression in p53 wild type tumors.  Dr. Sayeed received his PhD from the department of experimental medicine and biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, and conducted his postdoctoral studies in cancer biology at California Pacific Medical Center in San Francisco. Overall, Dr. Sayeed  has made conceptual advances in connecting signaling to gene expression to aggressive phenotypes, and paved the way for new directions in biomedical research.

Recent publications

  • Sayeed A, Lu H, Liu Q, Deming Li D, Duffy A, McCue P, Dicker AP, Davis RJ, Gabrilovich D, Rodeck U, Alteiri DC and Languino LR. β1 Integrins- and JNK-dependent tumor growth upon hypofractionated radiation Priority article, Oncotarget 2016, July 11.PMID: 27438371
  • Anindita Dutta, Jing Li, Carmine Fedele, Aejaz Sayeed, Amrita Singh, Shelia M. Violette, Thomas D. Manes and Lucia R Languino. αvβ6 Integrin Is Required for TGFβ1-Mediated Matrix Metalloproteinase 2 Expression. Biochem J. (2015) Jan 6. PMID: 25558779.
  • Sayeed, A., Fedele, C., Trerotola, M., Languino, L.R. IGF-IR Promotes Prostate Cancer Growth By Stabilizing a5b1 Integrin Protein Levels. PlosOne, (2013). e.76513. PMCID: PMC3793919
  • Sayeed A, Luciani G, Meng Z, Ling E and Dairkee SH. BST2 expression is a characteristic of high grade breast cancer  and leads to endocrine  resistance regardless of estrogen receptor status.  PLoSOne, (2013) 8(6), e67191. PMCID: PMC3688682
  • Sayeed, A., Goel, H.,Breen, M., Zarif, M.J., Garlick, D.S., Leav, I., Davis, R.J., FitzGerald, T.J., Morrione, A., Liu, Q., Dicker, A., Altieri, D.C., and Languino, L.R. β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting JNK. Cell Physiol., (2013), 228(7):1601- 1609. PMCID: PMC3749928.
  • Sayeed, A., Alam, N., Trerotola, M., and Languino, L.R. Insulin-Like Growth Factor 1 Stimulation of Androgen Receptor Activity Requires 1A J. Cell Physiol., 227:751-758 (2012). PMCID: PMC3195902
  • Saxena, P., Trerotola, M., Wang, T., Li, J., Sayeed, A., VanOudenhove, J., Adams, D.S., FitzGerald, T.J., Altieri, D.C., and Languino, L.R. PSA is required for androgen receptor expression in prostate cancer cells.  The Prostate, 72:769-776 (2012). PMCID: PMC3404455
  • Goodson W, Luciani G, Sayeed A, Jafee I, Moore DH and Dairkee SH. Minimum concentrations of bisphenol-A(BPA) and methyl paraben (MP) induce pro survival functional changes in non malignant human breast epithelial cells. Carcinogenesis, 32(11): 1724-33, 2011.PMCID: PMC3204351
  • Gloria Luciani, Junhee Seok, Aejaz Sayeed, Stacey Champion, William H Goodson, Stefanie S Jeffrey, Wenzhong Xiao, Michael Mindrinos, Ronald W Davis and Dairkee SH. Distinctive responsiveness to stromal signaling accompanies histologic grade programming of cancer cells. PLoSOne: (2011) 6(5), e20016. PMCID: PMC3098270
  • Sayeed A, Ling E, Meng Z, Luciani G and Dairkee SH. Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer. Cell Death and Disease, Jul 15;1:e53, 2010 .PMCID: PMC3032562
  • Shanaz Dairkee, Aejaz Sayeed, Gloria Luciani, Stacey Champion, Zenhang Meng, Lakshmi R Jakula, Heidi Feiler, Joe W. Gray, and Dan H. Moore. Immutable functional  attributes  of histologic grade revealed by context-independent gene expression in primary breast cancer cells. Cancer Research, 69(19), 7826-7834 (2009). PMCID: PMC2757757
  • Shanaz H. Dairkee, Junhee Seok, Stacey Champion, Aejaz Sayeed, Michael Mindrinos, Ronald W Davis and William H Goodson.  Bisphenol A induces a profile of tumor aggressiveness in high risk cells of breast cancer patients.  Cancer Research,  68(7), 2076-2080 (2008). PMID: 18381411
  • Aejaz Sayeed, Santi Konduri, Wensheng  Liu, Sanjay Bansal, and Gokul Das. Estrogen Receptor alpha alleviates p53-mediated transcriptional  repression: Implications for the regulation of Apoptosis. Cancer Research, 67(16), 7746-7755 (2007). PMID: 17699779
  • Dairkee SH, Nicolau M, Aejaz Sayeed,  Champion S, Ji Y, Moore DH, Yong B, Meng Z, Jeffrey SS,. Oxidative stress pathways highlighted in tumor cell immortalization; Association with breast cancer outcome. Oncogene, 26(43):6269-6279 (2007). PMID: 17471242
  • Zheng Li, Zhen Hang Meng, Aejaz Sayeed, Refaat Shalaby, Britt-Marie Ljung and Shanaz H. Dairkee. Genome –wide allelotyping of a new in-vitro model system reveals early events in breast cancer progression. Cancer Research, 62(20): 5980-5987, 2002. PMID:12384566
  • Aejaz Sayeed, H.Vohra, Anu Gupta and N.K.Ganguly. Apoptosis and its molecular machinery. Current Science, 80(3): 349-360, 200