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Director, Advanced Cardiac Imaging

LOCATION(S)
Department of Cardiology
100 North Academy Avenue
Danville, PA 17822 
Phone: 570-214-1991
Fax: 570-214-1480 
vcmehra@geisinger.edu

Research Interests

Advanced cardiac imaging techniques continue to evolve and add to our ability to finesse the cardiovascular disease phenotype. This has tremendous value in being able to risk stratify the diverse disease phenotype of heart disease. As part of Geisinger’s innovative model of health care delivery, advanced imaging modalities are being rapidly implemented across a large patient population thus giving us large amounts of imaging data from which to draw many important lessons about disease mechanism risk stratification, comparative and cost effectiveness and patient outcomes, all of which will have tremendous long term implications.  My interest is three-fold: First, to create a large, state of art imaging dataset using cardiac MRI in common and rare cardiovascular diseases by performing clinically indicated imaging. This will help improve patients’ outcomes directly by use of the superior technology but also provide opportunities to analyze this imaging dataset in unique ways to help answer important clinical and research questions. Second, to link the imaging dataset to an already robust EHR to create predictive models of disease risk. Lastly, to use the above resources to better understand genomic correlates of disease risk and progression by linking them to genomic data derived at Geisinger.

Recent Publications 

  • George RT, Mehra VC, Chen MY, Kitagawa K, Arbab-Zadeh A, Miller JM, Matheson MB, Vavere AL, Kofoed KK, Rochite CE, Dewey M, Yaw TS, Ninuma H, Brenner W, Cox C, Clouse ME, Lima JAC, Di Carli, M. (2014, Aug). Myocardial CT perfusion imaging and SPECT for the diagnosis of coronary artery disease: a head to head comparison from the COR320 multicenter diagnostic performance study. Radiology , 272 (2) 407-416. Full Text
  • Rochitte CE, George RT, Chen MY, Arbab-Zadeh A, Dewey M, Miller JM, Niinuma H, Yoshioka K, Kitagawa K, Nakamori S, Laham R, Vavere AL, Cerci RJ, Mehra VC, Nomura C, Kofoed KF, Jinzaki M, Kuribayashi S, de Roos A, Laule M, Yaw TS, Hoe J, Paul N, Rybicki FJ, Brinker JA, Arai AE, Cox C, Clouse ME, Di Carli MF, Lim JAC. (2014, May). Computed Tomography Angiography and Perfusion to Assess Coronary Artery Stenosis Causing Perfusion Defects by Single Photon Emission Computed Tomography: The CORE320 Study. European Heart Journal , 35 (17)1120-1130. Full Text
  • Mehra VC, Jackson E, Zhang X, Dobrucki LW, Jun Yu, Bernatchez P, Yarovinsky T, Sinusas AJ, Shulman GI, Sessa WC, Bender JR. (2014, May). Ceramide-activated Phosphatase Mediates Fatty Acid-induced Mammalian Endothelial VEGF Resistance and Impaired Murine Angiogenesis. American Journal of Pathology , 184 (5) 1562-1576. Full Text
  • George RT, Mehra VC, Saraste A, Knuuti, J. (2012). Myocardial perfusion by CT vs. hybrid imaging. Cardiology Clinics , 301(1)135-146. Full Text
  • Mehra VC, Valdiviezo C, Arbab-Zadeh A, Ko B, Seneviratne S, Cerci R, Lima JAC, George RT. (2011, Dec). A Stepwise Approach to Visual Interpretation of CT-based Myocardial Perfusion. Journal of Cardiovascular CT , 5(6):357-369. Full Text

Education

MD, Univeristy of Delhi School of Medicine, 1995
PhD, Yale University, 2008
Fellowship in Cardiology, Johns Hopkins University, 2011
Research Associate, National Institutes of Health, 2014
Assistant Professor, Johns Hopkins Medicine, 2014