Research InterestsUltimately, our group is interested in the translation of research findings to meaningful changes in clinical care and improved outcomes for individuals with autism spectrum disorder (ASD), intellectual disability (ID), and other neurodevelopmental disorders (NDD). Elucidation of the pathophysiologic processes involved in the various etiologic subtypes of ASD and other NDD (as well as sub-phenotypes that cross traditional diagnostic classification boundaries) will be necessary to allow medical treatment to progress from modification of broad behavioral symptoms to neuroprotective or restorative interventions.
We hope to identify genetic factors that underlie variation in brain structure and function, influence disease state and/or important quantitative sub-phenotypes, and moderate response to specific therapeutic interventions through both “genotype first” approach (including detailed phenotyping of individuals with specific genetic etiologies associated with ASD and other NDD), and a “phenotype first” approach (exploring the genetic underpinnings of behavioral, cognitive, and physical sub-phenotypes within and across categorical diagnoses).
I am also interested in helping to delineate the effects of medications on basic operant behavioral processes and evaluating the value of integrating behavioral and pharmacological interventions in the treatment of problem behaviors associated with NDDs.
- Lazar SM, Evans DE, Myers SM, Moreno De Luca A, Moore GJ . (2014, Apr). Social Cognition and Neural Substrates of Face Perception: Implications for Neurodevelopmental and Neuropsychiatric Disorders. Behavioural Brain Research , 263,1-8. Full Text
- Shea L, Newschaffer CJ, Xie M, Myers SM, Mandell DS. (2014, Jan). Genetic testing and genetic counseling among Medicaid-enrolled children with autism spectrum disorder in 2001 and 2007. Human Genetics , 133(1),111-6. Full Text
- Myers SM. (2013). Diagnosing Developmental Disabilities. In Batshaw ML, Roizen NJ, Lotrecchiano GR (Eds.). Children With Disabilities, 7th Ed. Brookes, Baltimore , 243-266.
- Moreno-De-Luca A, Myers SM, Challman TD, Moreno-De-Luca D, Evans DW, Ledbetter DH. (2013, April). Developmental brain dysfunction (DBD): Revival and expansion of old concepts based on new genetic evidence. Lancet Neurology , 12(4):406-14. Full Text
- Moreno-De-Luca D, SGENE Consortium, Mulle JG, Simons Simplex Collection Genetics Consortium, Kaminsky EB, Sanders SJ, Gene STAR, Myers SM, Adam MP, Pakula AT, Eisenhauer NJ, Uhas K, Weik L, Guy L, Care ME, Morel CF, Boni C, Salbert BA, Chandrareddy A, Demmer LA, Chow EWC, Surti U, Aradhya S, Pickering DL, Golden DM, Sanger WG, Aston E, Brothman AR, Gliem TJ, Thorland EC, Ackley T, Iyer R, Huang S, Barber JC, Crolla JA, Warren ST, Martin CL, Ledbetter DH. (2010, Nov). Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia. The American Journal of Human Genetics , 87(5),618-630. Full Text