Michael Murray
Director of Clinical Genomics

LOCATION(S)
Genomic Medicine Institute
190 Welles Street Suite 128
Forty Fort, PA 18704 
Phone: 570-714-6420
mfmurray1@geisinger.edu

Research Interests 

  • Application of genomics to patient care
  • Population screening with genomic sequencing
  • Genetics and Genomics
  • Pharmacogenetics
  • Rare diseases

Recent Publications

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.
Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, Lopez A, Penn J, Zhao A, Shao W, Stahl N, Murphy AJ, Hamon S, Bouzelmat A, Zhang R, Shumel B, Pordy R, Gipe D, Herman GA, Sheu WHH, Lee IT, Liang KW, Guo X, Rotter JI, Chen YI, Kraus WE, Shah SH, Damrauer S, Small A, Rader DJ, Wulff AB, Nordestgaard BG, Tybjærg-Hansen A, van den Hoek AM, Princen HMG, Ledbetter DH, Carey DJ, Overton JD, Reid JG, Sasiela WJ, Banerjee P, Shuldiner AR, Borecki IB, Teslovich TM, Yancopoulos GD, Mellis SJ, Gromada J, Baras A.
N Engl J Med. 2017 Jul 20;377(3):211-221. doi: 10.1056/NEJMoa1612790. Epub 2017 May 24.
PMID: 28538136
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The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial.
Vassy JL, Christensen KD, Schonman EF, Blout CL, Robinson JO, Krier JB, Diamond PM, Lebo M, Machini K, Azzariti DR, Dukhovny D, Bates DW, MacRae CA, Murray MF, Rehm HL, McGuire AL, Green RC; MedSeq Project.
Ann Intern Med. 2017 Jun 27. doi: 10.7326/M17-0188. [Epub ahead of print]
PMID: 28654958
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Evaluating the Clinical Validity of Gene-Disease Associations: An Evidence-Based Framework Developed by the Clinical Genome Resource.
Strande NT, Riggs ER, Buchanan AH, Ceyhan-Birsoy O, DiStefano M, Dwight SS, Goldstein J, Ghosh R, Seifert BA, Sneddon TP, Wright MW, Milko LV, Cherry JM, Giovanni MA, Murray MF, O'Daniel JM, Ramos EM, Santani AB, Scott AF, Plon SE, Rehm HL, Martin CL, Berg JS.
Am J Hum Genet. 2017 Jun 1;100(6):895-906. doi: 10.1016/j.ajhg.2017.04.015. rel="noopener noreferrer" Epub 2017 May 25.
PMID: 28552198
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Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S.
Circ Res. 2017 Jun 23;121(1):81-88. doi: rel="noopener noreferrer" 10.1161/CIRCRESAHA.117.311145. Epub 2017 May 15.
PMID: 28506971
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Electronic health record phenotype in subjects with genetic variants associated with arrhythmogenic right ventricular cardiomyopathy: a study of 30,716 subjects with exome sequencing.
Haggerty CM, James CA, Calkins H, Tichnell C, Leader JB, Hartzel DN, Nevius CD, Pendergrass SA, Person TN, Schwartz M, Ritchie MD, Carey DJ, Ledbetter DH, Williams MS, Dewey FE, Lopez A, Penn J, Overton JD, Reid JG, Lebo M, Mason-Suares H, Austin-Tse C, Rehm HL, Delisle BP, Makowski DJ, Mehra VC, Murray MF, Fornwalt BK.
Genet rel="noopener noreferrer" Med. 2017 Nov;19(11):1245-1252. doi: 10.1038/gim.2017.40. Epub 2017 May 4.
PMID: 28471438
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Adding Protective Genetic Variants to Clinical Reporting of Genomic Screening Results: Restoring Balance.
Schwartz MLB, Williams MS, Murray MF.
JAMA. 2017 Apr 18;317(15):1527-1528. doi: 10.1001/jama.2017.1533. No abstract available. 
PMID: 28288260
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Genetic identification of familial hypercholesterolemia within a single U.S. health care system.
Abul-Husn NS, Manickam K, Jones LK, Wright EA, Hartzel DN, Gonzaga-Jauregui C, O'Dushlaine C, Leader JB, Lester Kirchner H, Lindbuchler DM, Barr ML, Giovanni MA, Ritchie MD, Overton JD, Reid JG, Metpally RP, Wardeh AH, Borecki IB, Yancopoulos GD, Baras A, Shuldiner AR, Gottesman O, rel="noopener noreferrer" Ledbetter DH, Carey DJ, Dewey FE, Murray MF.
Science. 2016 Dec 23;354(6319). pii: aaf7000. doi: 10.1126/science.aaf7000.
PMID: 28008010
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Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study.
Dewey FE, Murray MF, Overton JD, Habegger L, Leader JB, Fetterolf SN, O'Dushlaine C, Van Hout CV, Staples J, Gonzaga-Jauregui C, Metpally R, Pendergrass SA, Giovanni MA, Kirchner HL, Balasubramanian S, Abul-Husn NS, Hartzel DN, Lavage DR, Kost KA, Packer JS, Lopez AE, Penn J, Mukherjee S, Gosalia N, Kanagaraj M, Li AH, Mitnaul LJ, Adams LJ, Person TN, Praveen K, Marcketta A, Lebo MS, Austin-Tse CA, Mason-Suares HM, Bruse S, Mellis S, Phillips R, Stahl N, Murphy A, Economides A, Skelding KA, Still CD, Elmore JR, Borecki IB, Yancopoulos GD, Davis FD, Faucett WA, Gottesman rel="noopener noreferrer" O, Ritchie MD, Shuldiner AR, Reid JG, Ledbetter DH, Baras A, Carey DJ.
Science. 2016 Dec 23;354(6319). pii: aaf6814. doi: 10.1126/science.aaf6814.
PMID: 28008009
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A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ε4 allele carriers.
Ayers KL, Mirshahi UL, Wardeh AH, Murray MF, Hao K, Glicksberg BS, Li S, Carey DJ, Chen R.
BMC Genomics. 2016 Jun 23;17 Suppl 2:445. doi: 10.1186/s12864-016-2725-z.
PMID: 27358062
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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.
Dewey FE, Gusarova V, O'Dushlaine C, Gottesman O, Trejos J, Hunt C, Van Hout CV, Habegger L, Buckler D, Lai KM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Ledbetter DH, Penn J, Lopez rel="noopener noreferrer" A, Borecki IB, Overton JD, Reid JG, Carey DJ, Murphy AJ, Yancopoulos GD, Baras A, Gromada J, Shuldiner AR.
N Engl J Med. 2016 Mar 24;374(12):1123-33. doi: 10.1056/NEJMoa1510926. Epub 2016 Mar 2.
PMID: 26933753
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The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine rel="noopener noreferrer" research.
Carey DJ, Fetterolf SN, Davis FD, Faucett WA, Kirchner HL, Mirshahi U, Murray MF, Smelser DT, Gerhard GS, Ledbetter DH.
Genet Med. 2016 Sep;18(9):906-13. doi: 10.1038/gim.2015.187. Epub 2016 Feb 11.
PMID: 26866580
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Your DNA is not your diagnosis: getting diagnoses right following secondary genomic findings.
Murray MF.
Genet Med. 2016 Aug;18(8):765-7. doi: 10.1038/gim.2015.134. Epub 2015 Oct 8. No abstract available. 
PMID: 26447529
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Education

MD, Pennsylvania State College of Medicine, 1984-1988
Resident Internal Medicine, Cleveland Clinic Foundation, 1988-1991
Fellow Infectious Diseases, University of Pennsylvania, 1991-1995
Fellow Medical Genetics, Harvard Medical School, 2000-2003