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Michael Bordonaro, PhD

Associate Professor of Molecular Biology
Department of Medical Education
North Campus

LOCATION(S)
Geisinger Commonwealth School of Medicine
Medical Sciences Building
525 Pine St.
Office 3044
Scranton, PA 18509
570-504-9646
Fax: 570-504-9636
mbordonaro@som.geisinger.edu

Michael Bordonaro, PhD

Michael Bordonaro, PhD, is associate professor of molecular biology in the Department of Medical Education. Dr. Bordonaro holds a PhD in the biological sciences from Fordham University, Bronx, N.Y. Additionally, Dr. Bordonaro completed a postdoctoral fellowship in the Department of Oncology at the Montefiore Medical Center, Bronx, N.Y., where he received an American Institute for Cancer Research Postdoctoral Award for his work on the effects of dietary components on the development of colorectal cancer. Dr. Bordonaro later held the position of associate research scientist at the Yale University School of Medicine and has also served as a research coordinator for Keren Pharmaceutical.

Recent publications

  • Lazarova, D., Bordonaro, M.  Hypothesis: ZEB1 mediates drug resistance and EMT in p300-deficient CRC. J Cancer  8: 1453-1459 (2017).
  • Bordonaro, M., Shirasawa, S, and Lazarova, D.L.  In hyperthermia increased ERK and WNT signaling suppress colorectal cancer cell growth.  Cancers 8:49 (2016).
  • Cho, Y., Gutierrez, L., Bordonaro, M., Russo, D., Anzelmi,‎ F.,  Hooven, J.T., Cerra, C., and Lazarova. D.L. Effects of propolis and gamma-cyclodextrin on intestinal neoplasia in normal weight and obese mice. Cancer Medicine 5: 2448-2458 (2016).
  • Lazarova, D.L., and Bordonaro, M.  Vimentin, colon cancer progression and resistance to butyrate and other HDACis.  J. Cell. Mol. Med. 20: 989-993 (2016).
  • Bordonaro, M., and Lazarova, D.L. Determination of the role of CBP and p300 mediated Wnt signaling on colonic cells. JMIR Res. Protoc.  5: e66 (2016).
  • Bordonaro, M., and Lazarova, D.L. Obesity is associated with a lower mutation threshold in colon cancer. J. Cancer 6: 825-831 (2015).
  • Bordonaro, M., and Lazarova, D.L. CBP, p300, butyrate, and Wnt signaling in colorectal cancer.  World J. Gastroenterology 21: 8238-8248 (2015).
  • Bordonaro, M., Drago, E., Atamna, W., and Lazarova, D.L. Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy. PLoS One 9: e115068 (2014).
  • Bordonaro, M., Chiaro, C.R., and May T. Experimental design to evaluate directed adaptive mutation in mammalian cells. JMIR Res. Protoc.  3:e74 (2014).
  • Bordonaro, M., and Lazarova, D.L. Hypothesis: cell signaling influences age-related risk of colorectal cancer. J. Cell. Mol. Med. 19: 74-81 (2014).
  • Lazarova, D.L., Chiaro, C., and Bordonaro, M.  Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells. BMC Research Notes 7: 226 (2014).
  • Bordonaro, M., and Lazarova, D.L. Butyrate, WNT signaling, and colorectal cancer.  In: Butyrate: Food sources, functions and health benefits. Nova Science Publishers, Inc. (Hauppauge, NY) (2014).
  • Zeng, H., Lazarova, D.L., and Bordonaro, M. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J. Gastrointestinal Oncol. 6 (2): 1-10 (2014).
  • Lazarova, D.L., Lee, A., Wong, T., Marian, B., Chiaro, C., Rainey, C., and Bordonaro, M.  Modulation of Wnt Activity and cell physiology by butyrate in LT97 microadenoma cells. J. Cancer 5: 203-213 (2014).
  • Bordonaro, M., Venema, K., Putri, A.K., and Lazarova, D.L. Approaches that ascertain the role of dietary compounds in colonic cancer cells. World J. Gastrointestinal Oncol. 6 (1): 1-10 (2014).
  • Drago, E., Bordonaro, M., Lee, S., Atamna, W., and Lazarova, D.L. Propolis augments apoptosis induced by butyrate via targeting cell survival pathways. PLoS One 8:e73151 (2013).
  • Lazarova, D.L., Wong, T., Chiaro, C., Drago, E., and Bordonaro, M. p300 influences butyrate-mediated WNT hyperactivation in colorectal cancer cells. J. Cancer 4: 491-501 (2013).
  • Lazarova, D.L., Chiaro, C., Wong, T., Drago, E., Rainey, A., O’Malley, S., and Bordonaro, M.  CBP activity mediates effects of the histone deacetylase inhibitor butyrate on WNT activity and apoptosis in colon cancer cells. J. Cancer 4: 481-490 (2013).
  • Bordonaro, M., and Ogryzko, V. Quantum biology at the cellular level-elements of the research program. BioSystems 112:11-30 (2013).
  • Bordonaro, M. Minireview: Crosstalk between Wnt signaling and RNA processing in colorectal cancer. J. Cancer 4: 96-103 (2013).
  • Chiaro, C., Lazarova, D.L., and Bordonaro, M.  Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells. Biochem. Biophys. Res. Commun. 428: 121-126 (2012).
  • Lazarova, D.L., and Bordonaro, M.  Extreme fluctuations in Wnt/beta-catenin signaling as an approach for colon cancer prevention and therapy. Advanced Studies in Biology 4: 351-362 (2012).
  • Bordonaro, M., Tewari, S., Cicco, C.E., Atamna, W., and Lazarova, D.L. A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells.  PLoS One 6:e27308 (2011).
  • Bordonaro, M., Tewari, S., Atamna, W., and Lazarova, D.L. The notch ligand Delta-like 1 integrates inputs from TGFBeta/Activin and Wnt pathways. Exp. Cell Res. 317: 1368-1381 (2011).
  • Bordonaro, M. Modular Cre/lox system and genetic therapeutics for colorectal cancer. J. Biomed. Biotechnol.  2009:358230 (2009).
  • Bordonaro, M. Chapter 19 role of wnt signaling in the development of type 2 diabetes. Vitam. Horm. 80: 563-581 (2009).
  • Bordonaro, M., Lazarova, D.L., and Sartorelli, A.C.  Role of Tcf-DNA binding and the chromatin remodeling factor Brg-1 in the modulation of Wnt activity by butyrate. Cell Cycle 7: 3472-3473 (2008).
  • Bordonaro, M., and Sartorelli, A.C. Fiber, cancer stem cells, and the Wnt signaling continuum: possibilities for colorectal cancer prevention and therapeutics. Chinese J. Cancer (Ai Zheng), 27: 766-770 (2008).
  • Bordonaro, M., Lazarova, D.L., and Sartorelli, A.C. Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?  Cell Cycle 7:9:1178-1183 (2008).
  • Bordonaro, M., Lazarova, D.L., and Sartorelli, A.C. Hyper-induction of Wnt activity: a new paradigm for the treatment of colorectal cancer? Oncol. Res. 17: 1-9 (2008).
  • Bordonaro, M.*, Lazarova, D.L.*, and Sartorelli, A.C.  The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors.  Exp. Cell Res. 313: 1652-1666 (2007).
  • Bordonaro, M., Lazarova, D.L., Carbone, R., and Sartorelli, A.C.  Modulation of Wnt-specific colon cancer cell kill by butyrate and lithium.  Oncol. Res. 14: 427-438 (2004).
  • Bordonaro, M., Lazarova, D. L., and Sartorelli, A. C.  Pharmacological and genetic modulation of Wnt-targeted cre lox-mediated gene expression in colorectal cancer cells.  Nucleic Acids Res. 32:  2660-2674 (2004).
  • Bordonaro, M., Lazarova, D.L., Augenlicht, L.H., and Sartorelli, A.C. Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. Int. J. Cancer 97:  42-51 (2002).
  • Lazarova, D.L., Bordonaro, M., and Sartorelli. A.C. Transcriptional regulation of the vitamin D(3) receptor gene by ZEB.  Cell Growth Differ. 12: 319-326 (2001).
  • Mariadason, J.M., Bordonaro, M., Aslam, F., Shi, L., Kuraguchi, M., Velcich, A., and Augenlicht, L.H. Downregulation of the beta-catenin-Tcf pathway is linked to colonic epithelial cell cycle arrest and differentiation.  Cancer Res. 61: 3465-3471 (2001).
  • Bordonaro, M., Mariadason, J.M., Aslam, F., Heerdt, B.G., and Augenlicht, L.H. Butyrate induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway, and concordance with effects of sulindac and trichostatin A, but not curcumin. Cell Growth Differ. 10: 713-720 (1999).
  • Augenlicht, L.H., Bordonaro, M., Heerdt, B.G., Mariadason, J., and Velcich, A. Cellular mechanisms of risk and transformation. Ann. NY Acad. Sci. 889: 20-31 (1999).
  • Augenlicht, L., Velcich, A., Mariadason, J., Bordonaro, M., and Heerdt, B. Colonic cell proliferation, differentiation, and apoptosis. Adv. Exp. Med. Biol. 470: 15-22 (1999).
  • Bordonaro, M., and Augenlicht, L.H. The 3′ untranslated region of the carcinoembryonic antigen gene plays a minimal role in the regulation of gene expression. Cell Growth Differ. 8: 353-360 (1997).
  • Bordonaro, M., Saccomanno, C.F., and Nordstrom, J.L. An improved T1/A ribonuclease protection assay. Biotechniques 16: 428-430 (1994).
  • Bordonaro, M. and Nordstrom, J.L. Different mechanisms are responsible for the low accumulation of transcripts from intronless and 3′ splice site deleted genes. Biochem. Biophys. Res. Comm. 203: 128-132 (1994).
  • Saccomanno, C.F., Bordonaro, M., Chen, J.S., and Nordstrom, J.L. A faster ribonuclease protection assay. Biotechniques 13: 846-850 (1992).

Education

Bachelor – SUNY-Binghamton, Binghamton, NY
Master – Fordham University, Bronx, NY
PhD – Fordham University, Bronx, NY
Postdoctoral – Montefiore Medical Center, Bronx, NY