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Department of Population Health Sciences

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Department Chair :
H. Lester Kirchner, PhD :
570-214-8688

The Department of Population Health Sciences works to discover novel ways to prevent disease and promote health, with a focus on the health conditions that most impact Geisinger patients, health plan members, and communities. We conduct innovative research to understand the risk factors of the disease and develop strategies to improve healthcare delivery. Our interdisciplinary faculty study a range of health conditions, collaborating with Geisinger clinicians and community partners and leveraging extensive data resources, including longitudinal electronic health records and insurance claims, geocoded data on the social and physical environment of communities, and genotyped and whole-exome sequencing data.

Core focus areas include:

  • Epidemiology: Examining the extent and distribution of the health conditions that most impact our patients and communities and identifying the factors that put populations at risk for disease
  • Biostatistics: Applying advanced quantitative analysis to observational data to draw valid conclusions from research studies, application of machine learning for the development of predictive models, and linking health and genomic data to understand the genetic architecture of complex diseases
  • Health and behavioral outcomes research: Detecting, preventing and controlling chronic conditions through the study of health-related behaviors, healthcare practices and health-related quality of life
  • Environmental health: Evaluating how the surrounding built, natural and social environment impacts health and enables or constrains the influence of healthcare
  • Health economics: Conducting comparative effectiveness research to identify the healthcare interventions that offer the greatest benefit at the lowest cost

Chair

H. Lester Kirchner, PhD

Faculty

Lisa Bailey-Davis, DEd, RD
Joseph Boscarino, PhD, MPH
Alexander Chang, MD, MS
Tullika Garg, MD, MPH
Jamie A Green, MD, MS
Jing Hao, PhD, MD
Annemarie G Hirsch, PhD, MPH
Yirui (Iris) Hu, PhD
Anne Justice, PhD
Sean O’Dell, PhD
Melissa N. Poulsen, PhD, MPH
Brian S. Schwartz, MD, MS
Erin Van Enkevort, PhD
Brent Williams, PhD

Staff scientists

Geetha Chittoor, PhD

 

Recent publications

Recent publications

Hirsch AGPoulsen MN, Nordberg C, Moon KA, Rebman A, Aucott J, Heaney CD, Schwartz BS. Risk factors and outcomes of treatment delays in Lyme disease: A population-based retrospective cohort study. Frontiers in Medicine, 2020 (in press). PMCID:  PMC6009554.

Hirsch AG, Carson AP, Lee NL, McAlexander T, Mercado C, Siegel K, Black NC, Elbel B, Long DL, Lopez P, McClure LA, Poulsen MNSchwartz BS, Thorpe LE. The Diabetes Location, Environmental Attributes, and Disparities Network: Protocol for Nested Case Control and Cohort Studies, Rationale, and Baseline Characteristics. JMIR Res Protoc, 2020; 9(10): e21377. doi: 10.2196/21377.

Lisa Bailey-Davis, G. Craig Wood, Adam Cook, Krystal Cunningham, Scott Jamieson, Jacob Mowery, Allison Naylor , David D. Rolston, Christopher Seiler, Christopher D. Still. Communicating personalized risk of diabetes and offering weight reduction program choice: Recruitment, participation, and outcomes. doi: 10.1016/j.pec.2020.10.17.

Chang AR, Kramer H, Wei G, Boucher R, Grams ME, Berlowitz D, Bhatt U, Cohen DL, Drawz P, Punzi H, Freedman BI, Haley W, Hawfield A, Horwitz E, McLouth C, Morisky D, Papademetriou V, Rocco MV, Wall B, Weiner DE, Zias A, Beddhu S; SPRINT Research Group. Effects of Intensive Blood Pressure Control in Patients with and without Albuminuria: Post Hoc Analyses from SPRINT. Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1121-1128. doi: 10.2215/CJN.12371019. Epub 2020 Jul 15. PMID: 32669306.

This article selected as “Best of the American Society of Nephrology Journals” session for the ASN Kidney Week 2020

Shin JI, Sang Y, Chang AR, Dunning SC, Coresh J, Inker LA, Selvin E, Ballew SH, Grams ME. The FDA Metformin Label Change and Racial and Sex Disparities in Metformin Prescription among Patients with CKD. J Am Soc Nephrol. 2020 Aug;31(8):1847-1858. doi: 10.1681/ASN.2019101119. Epub 2020 Jul 13. PMID: 32660971.

Sumida K, Nadkarni GN, Grams ME, Sang Y, Ballew SH, Coresh J, Matsushita K, Surapaneni A, Brunskill N, Chadban SJ, Chang AR, Cirillo M, Daratha KB, Gansevoort RT, Garg AX, Iacoviello L, Kayama T, Konta T, Kovesdy CP, Lash J, Lee BJ, Major RW, Metzger M, Miura K, Naimark DMJ, Nelson RG, Sawhney S, Stempniewicz N, Tang M, Townsend RR, Traynor JP, Valdivielso JM, Wetzels J, Polkinghorne KR, Heerspink HJL. Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis: An Individual Participant-Based Meta- analysis. Ann Intern Med. 2020 Jul 14. doi: 10.7326/M20-0529. Epub ahead of print. PMID: 32658569.

Qiao Y, Shin JI, Chen TK, Inker LA, Coresh J, Alexander GC, Jackson JW, Chang AR, Grams ME. Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate. JAMA Intern Med. 2020 May 1;180(5):718-726. doi: 10.1001/jamainternmed.2020.0193. PMID: 32150237; PMCID: PMC7063544.

Titan SM, Laureati P, Sang Y, Chang AR, Evans M, Trevisan M, Levey AS, Grams ME, Inker LA, Carrero JJ. Bisphosphonate utilization across the spectrum of eGFR. Arch Osteoporos. 2020 May 9;15(1):69. doi: 10.1007/s11657-020-0702-2. PMID: 32385586.

Juraschek SP, Kovell LC, Appel LJ, Miller ER 3rd, Sacks FM, Christenson RH, Rebuck H, Chang AR, Mukamal KJ. Associations Between Dietary Patterns and Subclinical Cardiac Injury: An Observational Analysis From the DASH Trial. Ann Intern Med. 2020 Jun 16;172(12):786-794. doi: 10.7326/M20-0336. Epub 2020 May 19. PMID: 32423348; PMCID: PMC7388686.

Juraschek SP, Miller ER 3rd, Chang AR, Anderson CAM, Hall JE, Appel LJ. Effects of Sodium Reduction on Energy, Metabolism, Weight, Thirst, and Urine Volume: Results From the DASH (Dietary Approaches to Stop Hypertension)-Sodium Trial. Hypertension. 2020 Mar;75(3):723-729. doi: 10.1161/HYPERTENSIONAHA.119.13932. Epub 2020 Jan 20. PMID: 31957521; PMCID: PMC7278848

Garg T, McMullen CK, Leo MC, O'Keeffe-Rosetti MC, Weinmann S, Nielsen ME. Predicting risk of multiple levels of recurrence and progression after initial diagnosis of nonmuscle-invasive bladder cancer in a multisite, community-based cohort. Cancer. 2020 Nov 4. doi: 10.1002/cncr.33300. Epub ahead of print. PMID: 33146913.


 

Full Publications

Publications 2020

Hirsch AGPoulsen MN, Nordberg C, Moon KA, Rebman A, Aucott J, Heaney CD, Schwartz BS. Risk factors and outcomes of treatment delays in Lyme disease: A population-based retrospective cohort study. Frontiers in Medicine, 2020 (in press). PMCID:  PMC6009554.

Hirsch AG, Carson AP, Lee NL, McAlexander T, Mercado C, Siegel K, Black NC, Elbel B, Long DL, Lopez P, McClure LA, Poulsen MNSchwartz BS, Thorpe LE. The Diabetes Location, Environmental Attributes, and Disparities Network: Protocol for Nested Case Control and Cohort Studies, Rationale, and Baseline Characteristics. JMIR Res Protoc, 2020; 9(10): e21377. doi: 10.2196/21377.

Lisa Bailey-Davis, G. Craig Wood, Adam Cook, Krystal Cunningham, Scott Jamieson, Jacob Mowery, Allison Naylor , David D. Rolston, Christopher Seiler, Christopher D. Still. Communicating personalized risk of diabetes and offering weight reduction program choice: Recruitment, participation, and outcomes. doi: 10.1016/j.pec.2020.10.17.

Chang AR, Kramer H, Wei G, Boucher R, Grams ME, Berlowitz D, Bhatt U, Cohen DL, Drawz P, Punzi H, Freedman BI, Haley W, Hawfield A, Horwitz E, McLouth C, Morisky D, Papademetriou V, Rocco MV, Wall B, Weiner DE, Zias A, Beddhu S; SPRINT Research Group. Effects of Intensive Blood Pressure Control in Patients with and without Albuminuria: Post Hoc Analyses from SPRINT. Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1121-1128. doi: 10.2215/CJN.12371019. Epub 2020 Jul 15. PMID: 32669306.

This article selected as “Best of the American Society of Nephrology Journals” session for the ASN Kidney Week 2020

Shin JI, Sang Y, Chang AR, Dunning SC, Coresh J, Inker LA, Selvin E, Ballew SH, Grams ME. The FDA Metformin Label Change and Racial and Sex Disparities in Metformin Prescription among Patients with CKD. J Am Soc Nephrol. 2020 Aug;31(8):1847-1858. doi: 10.1681/ASN.2019101119. Epub 2020 Jul 13. PMID: 32660971.

Sumida K, Nadkarni GN, Grams ME, Sang Y, Ballew SH, Coresh J, Matsushita K, Surapaneni A, Brunskill N, Chadban SJ, Chang AR, Cirillo M, Daratha KB, Gansevoort RT, Garg AX, Iacoviello L, Kayama T, Konta T, Kovesdy CP, Lash J, Lee BJ, Major RW, Metzger M, Miura K, Naimark DMJ, Nelson RG, Sawhney S, Stempniewicz N, Tang M, Townsend RR, Traynor JP, Valdivielso JM, Wetzels J, Polkinghorne KR, Heerspink HJL. Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis: An Individual Participant-Based Meta- analysis. Ann Intern Med. 2020 Jul 14. doi: 10.7326/M20-0529. Epub ahead of print. PMID: 32658569.

Qiao Y, Shin JI, Chen TK, Inker LA, Coresh J, Alexander GC, Jackson JW, Chang AR, Grams ME. Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate. JAMA Intern Med. 2020 May 1;180(5):718-726. doi: 10.1001/jamainternmed.2020.0193. PMID: 32150237; PMCID: PMC7063544.

Titan SM, Laureati P, Sang Y, Chang AR, Evans M, Trevisan M, Levey AS, Grams ME, Inker LA, Carrero JJ. Bisphosphonate utilization across the spectrum of eGFR. Arch Osteoporos. 2020 May 9;15(1):69. doi: 10.1007/s11657-020-0702-2. PMID: 32385586.

Juraschek SP, Kovell LC, Appel LJ, Miller ER 3rd, Sacks FM, Christenson RH, Rebuck H, Chang AR, Mukamal KJ. Associations Between Dietary Patterns and Subclinical Cardiac Injury: An Observational Analysis From the DASH Trial. Ann Intern Med. 2020 Jun 16;172(12):786-794. doi: 10.7326/M20-0336. Epub 2020 May 19. PMID: 32423348; PMCID: PMC7388686.

Juraschek SP, Miller ER 3rd, Chang AR, Anderson CAM, Hall JE, Appel LJ. Effects of Sodium Reduction on Energy, Metabolism, Weight, Thirst, and Urine Volume: Results From the DASH (Dietary Approaches to Stop Hypertension)-Sodium Trial. Hypertension. 2020 Mar;75(3):723-729. doi: 10.1161/HYPERTENSIONAHA.119.13932. Epub 2020 Jan 20. PMID: 31957521; PMCID: PMC7278848

Garg T, McMullen CK, Leo MC, O'Keeffe-Rosetti MC, Weinmann S, Nielsen ME. Predicting risk of multiple levels of recurrence and progression after initial diagnosis of nonmuscle-invasive bladder cancer in a multisite, community-based cohort. Cancer. 2020 Nov 4. doi: 10.1002/cncr.33300. Epub ahead of print. PMID: 33146913.

B T Keenan, H Kirchner, O J Veatch, K M Borthwick, V A Davenport, M Gendy, F Pack, L Sirikulvadhana, B A Malow, T I Morgenthaler, P C Zee, J D Robishaw, S F Derose, A I Pack. Multi-Site Validation of a Simple EHR-based Algorithm for Obstructive Sleep Apnea. JCSM (in press) *co-lead authors.  DOI: 10.5664/jcsm.8160

 

Publications 2019

Carruth ED, Young W, Beer D, James CA, Calkins H, Jing L, Raghunath S, Hartzel DN, Leader JB, Kirchner HL, Smelser DT, Carey DJ, Kelly MA, Sturm AC, Alsaid A, Fornwalt BK, Haggerty CM. Prevalence and Electronic Health Record-Based Phenotype of Loss-of-Function Genetic Variants in Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Genes. Circulation: Genomic and Precision Medicine, 2019;12(11):e002579. PMCID: PMC6726131

Casey JA, Goin DE, Rudolph KE, Schwartz BS, Mercer D, Elser H, Eisen EA, Morello-Frosch R. Unconventional natural gas development and adverse birth outcomes in Pennsylvania: The potential mediating role of antenatal anxiety and depression. Environ Research 2019; 177: in press. PMCID: PMC6726131

Hirsch AG, Nordberg C, Bandeen-Roche K, Tan BK, Schleimer RP, Kern RC, Sundaresan A, Pinto JM, Kennedy TL, Greene SC, Kuiper JR, Schwartz BS. Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample. Allergy. 2019. In press. PMID: 31713250

Hirsch AG, Nordberg C, Tan BK, Schleimer RP, Kern RC, Sundaresan AS, Pinto J, Kennedy TL, Greene S, Kuiper JR, Schwartz BS. Prevalence of sinus CT opacification in a population-based sample. Allergy 2019; in press. DOI: 10.1111/all.14106

B T Keenan, H Kirchner, O J Veatch, K M Borthwick, V A Davenport, M Gendy, F Pack, L Sirikulvadhana, B A Malow, T I Morgenthaler, P C Zee, J D Robishaw, S F Derose, A I Pack. Multi-Site Validation of a Simple EHR-based Algorithm for Obstructive Sleep Apnea. JCSM (in press) *co-lead authors

Zheutlin AB, Dennis J, Karlsson Linnér R, Moscati A, Restrepo N, Straub P, Ruderfer D, Castro VM, Chen CY, Ge T, Huckins LM, Charney A, Kirchner HL, Stahl EA, Chabris CF, Davis LK, Smoller JW. Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems. Am J Psychiatry, 2019;176(10):846-855. PMID: 31416338

Schmidlen T, Schwartz M, DiLoreto K, Kirchner HL, Sturm AC. Patient Assessment of Chatbots for the Scalable Delivery of Genetic Counseling. J Genet Couns, 2019;28(6):1166-1177. PMID: 31549758

Schmidt AF, Holmes MV, Preiss D, Swerdlow D, …., Kirchner HL, … Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani AD. Phenome-wide Association Analysis of LDL-Cholesterol Lowering Genetic Variants in PCSK9Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. BMC Cardiovascular Disorders, 2019:19:240. PMCID: PMC6820948

Wehner GJ, Jing L, Haggerty CM, Suever JD, Leader JB, Hartzel DN, Kirchner HL, Manus JNA, James N, Ayar Z, Gladding P, Good CW, Cleland JGF, Fornwalt BK. Routinely reported ejection fraction and mortality in clinical practice: where does the nadir of risk lie? European Heart Journal (in press) PMID: 31386109

Beer D, Sharma PS, Subzposh FA, Naperkowski A, Pietrasik GM, Durr B, Qureshi M, Panikkath R, Abdelrahman M, Williams BA, Hanifin JL, Zimberg R, Austin K, Macuch B, Trohman RG, Vanenkevort EA, Dandamudi G, Vijayaraman P.  Clinical Outcomes of Selective Versus Nonselective His Bundle Pacing. JACC Clin Electrophysiol, 2019;5(7):766-774. PMID: 31320004

Ladapo JA, Pfeifer JM, Pitcavage JM, Williams BA, Choy-Shan AA. Quantifying Sex Differences in Cardiovascular Care Among Patients Evaluated for Suspected Ischemic Heart Disease.  Journal of Women’s Health (Larchmt), 2019:28(5):698-704. PMCID: PMC6537115

BRENT WILLIAMS and PRANAV GANDHI.  A Risk Prediction Model for Heart Failure Hospitalization among Patients with Type 2 Diabetes. Clin Cardiol 2019 (in press). 

Abara WE, Spradling P, Zhong Y, Moorman A, Teshale EH, Rupp L, Gordon SC, Schmidt M, Boscarino JA, Daida YG, Holmberg SD; CHeCS Investigators. Hepatocellular Carcinoma Surveillance in a Cohort of Chronic Hepatitis C Virus-Infected Patients with Cirrhosis. J Gastrointest Cancer. 2019 May 23. DOI: 10.1007/s12029-019-00255-4. [Epub ahead of print] PMID: 31124041

Richard E. Adams, Thomas G. Urosevich, Stuart N. Hoffman, H. Lester Kirchner, Charles R. Figley, Carrie A. Withey, Joseph J. Boscarino, Ryan J. Dugan, and Joseph A. Boscarino. Social and Psychological Risk and Protective Factors for Veteran Well-Being: The Role of Veteran Identity and Its Implications for Intervention. Military Behavioral Health, 2019; 7(3):304-314. PMCID: PMC6666406.

Alvaro Alonso, MD, PhD,  Madison D. Anderson, MPH,  Michael P. Bancks, PhD, MPH,  Sherry‐Ann Brown, MD, PhD,  Melissa C. Caughey, PhD,  Alex R. Chang, MD, MS,  Erin Delker, MPH,  Kathryn Foti, MPH,  Véronique Gingras, PhD, RD,  Michael G. Nanna, MD, Alexander C. Razavi, BA, Jewel Scott, MSN, RN, FNP‐C, Elizabeth Selvin, PhD, MPH, Catherine Tcheandjieu, DVM, PhD, Alvin G. Thomas, MSPH, Ruth‐Alma N. Turkson‐Ocran, MPH, MSN, RN, FNP‐BC, Allison Webel, PhD, RN, FAAN, Deborah R. Young, PhD, FAHA, and Bailey M. DeBarmore, MHS, RD. Highlights From the American Heart Association's EPI|LIFESTYLE 2019 Scientific Sessions. J Am Heart Assoc. 2019 Jun 4;8(11):e012925. DOI: 10.1161/JAHA.119.012925. Epub 2019 Jun 1. PubMed PMID: 31433702. PMCID: PMC6585

L. Bailey‐Davis, S. M. R. Kling, G. C. Wood, W. J. Cochran, J. W. Mowery, J. S. Savage, R. A. Stametz, and G. J. Welk. Feasibility of enhancing well‐child visits with family nutrition and physical activity risk assessment on body mass index. Obesity Science & Practice, 2019. 5: 220– 230. PMCID: PMC6587309

Sarah E. Baker, Kehinde Ogundipe, Christopher Sterwald, Erin A. Van Enkevort & Adam Brenner. A Winning Case? Assessing the Effectiveness of a Mock Trial in a General Psychiatry Residency Program. Academic Psychiatry (2019). PMID: 31037652

Dominik Beer DO, Parikshit S. Sharma MD, MPH, Faiz A. Subzposh MD, Angela Naperkowski RN, Grzegorz M. Pietrasik MD, MPH, Brendan Durr DO, Maria Qureshi MD, Ragesh Panikkath MD, Mohamed Abdelrahman MD, Brent A. Williams PhD, Jillian L. Hanifin RN, Ryan Zimberg RN, Kelly Austin RN, Brooke Macuch RN, Richard G. Trohman MD, MBA, Erin A. Vanenkevort PhD, Gopi Dandamudi MD, Pugazhendhi Vijayaraman MD  (2019). Clinical Outcomes of Selective Versus Nonselective His Bundle Pacing. JACC: Clinical Electrophysiology. PMID: 31320004

Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS; Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019 Mar 5;139(10):e56-e528. DOI: 10.1161/CIR.0000000000000659. PMID: 30700139.

Amy R Bentley*, Yun J Sung*, Michael R Brown*, Thomas W Winkler*, Aldi T Kraja*, Ioanna Ntalla, …, Anne E Justice, et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019 Apr;51(4):636-648. DOI: 10.1038/s41588-019-0378-y. Epub 2019 Mar 29. PubMed PMID: 30926973. PMCID: PMC6467258.

Besse W, Chang AR, Luo JZ, Triffo WJ, Moore BS, Gulati A, Hartzel DN, Mane S; Regeneron Genetics Center, Torres VE, Somlo S, Mirshahi T. ALG9 Mutation Carriers Develop Kidney and Liver Cysts. J Am Soc Nephrol. 2019 Aug 8. pii:ASN.2019030298. DOI: 10.1681/ASN.2019030298. [Epub ahead of print].

PMCID: PMC6830805

Bixler D, Zhong Y, Ly KN, Moorman AC, Spradling PR, Teshale EH, Rupp LB, Gordon SC, Boscarino JA, Schmidt MA, Daida YG, Holmberg SD; CHeCS Investigators. Mortality Among Patients With Chronic Hepatitis B Infection: The Chronic Hepatitis Cohort Study (CHeCS). Clin Infect Dis. 2019 Mar 5;68(6):956-963. DOI: 10.1093/cid/ciy598. PMID: 30060032

Blankenship JC, Kirchner HL. Parsing the Patients of FREEDOM. J Am Coll Cardiol 2019;74:2085-2087.  PMID: 31623767

Boscarino JA, Adams RE, Urosevich TG, Hoffman SN, Kirchner HL, Dugan RJ, Boscarino JJ, Withey CA, Figley CR. Guard/Reserve service members and mental health outcomes following deployment: Results from the Veterans' Health Study. Gen Hosp Psychiatry. 2019 Mar 15. pii: S0163-8343(19)30109-4. DOI: 10.1016/j.genhosppsych.2019.03.002. [Epub ahead of print] PMID: 30910352.

Bradfield JP*, Vogelezang S*, Felix JF,… Justice AE, et al. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet. 2019 Jul 5. pii: ddz161. DOI: 10.1093/hmg/ddz161. PMCID: PMC6859434

Brodrick, B, Harper, JA, Van Enkevort, E,  McAdams, C. (2019). Treatment Utilization and Medical Problems in a Community Sample of Adult Women With Anorexia Nervosa. Frontiers in Psychology, Eating Behavior.  PMCID: PMC6509221

E. Sherwood Brown, Collette Bice, William C. Putnam, Richard Leff, Alexandra Kulikova, Alyson Nakamura, Elena I. Ivleva, Erin Van Enkevort, Traci Holmes, Nyokabi Miingi. (2019). Human safety and pharmacokinetics study of orally administered Icariin: Randomized, double-blind, placebo-controlled trial. Natural Product Communications, 1-6. DOI: 10.1177/1934578X19856789

Brown, E. S., Kulikova, A., Van Enkevort, E. A., Nakamura, A., Ivleva, E., Tustison, N., Roberts, J., Yassa, M., Choi, C., Frol, A., Khan, D., Vazquez, M., Holmes, T., & Malone, K. (2019). A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus. Neuropsychopharmacology, 2019;44(13):2263-2267. PMID: 31181564

Brown ES, Sayed , Choi C, Tustison N, Roberts J, Yassa MA, Van Enkevort E, Nakamura A, Ivleva EI, Sunderajan P, Khan DA, Vazquez M, McEwen B, Kulikova A, Frol AB, Holmes T. (2019). A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus. European Neuropsychopharmacology, 2019;29(3):376-383. PMID: 30612854

Alex R Chang, Lisa Bailey-Davis, Vonda Hetherington, Anna Ziegler, Christina Yule, Sara Kwiecen, Elisabeth Graboski, Melissa M Melough, Charlotte Collins, Cheryl Anderson. Remote Dietary Counseling Using Smartphone Applications in Patients With Stages 1-3a Chronic Kidney Disease: A Mixed Methods Feasibility Study. J Ren Nutr. 2019 May 8. pii:S1051-2276(19)30156-6. DOI: 10.1053/j.jrn.2019.03.080. [Epub ahead of print].  PMCID: PMC6842073

Chang AR, Bailey-Davis L, Yule C, Kwiecen S, Graboski E, Juraschek S, Krekel C, Collins C, Anderson C: Effects of Dietary App-Supported Tele-Counseling on Sodium Intake, Diet Quality, and Blood Pressure in Patients With Diabetes and Kidney Disease. Circulation. 2019 Mar 5;139(Suppl_1):AP289.  DOI: 10.1161/circ.139.suppl_1.P289

Alex R Chang, assistant professor, Morgan E Grams, associate professor, Shoshana H Ballew, assistant scientist, Henk Bilo, professor, Adolfo Correa, professor, Marie Evans, nephrologist, Orlando M Gutierrez, professor, Farhad Hosseinpanah, associate professor, Kunitoshi Iseki, director, Timothy Kenealy, associate professor, Barbara Klein, professor, Florian Kronenberg, professor, Brian J Lee, nephrologist, Yuanying Li, researcher, Katsuyuki Miura, professor, Sankar D Navaneethan, associate professor, Paul J Roderick, professor, Jose M Valdivielso, principal investigator, Frank L J Visseren, professor, Luxia Zhang, professor, Ron T Gansevoort, professor, Stein I Hallan, professor, Andrew S Levey, professor, Kunihiro Matsushita, associate professor, Varda Shalev, director, and Mark Woodward, professor, on behalf of the CKD Prognosis Consortium (CKD-PC). Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium. BMJ. 2019 Jan 10;364:k5301.  PMCID: PMC6481269

Shivani Daftary, Erin Van Enkevort, Alexandra Kulikova, Michael Legacy, E Sherwood Brown (2019). Relationship between depressive symptom severity and amygdala volume in a large community-based sample. Psychiatry Research: Neuroimaging, 283, 77-82 DOI: 10.1016/j.pscychresns.2018.12.005.  PMID: 30554129

Antoinette Sabatino DiCriscio, Yirui Hu, Vanessa Troiani. Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm. Journal of autism and developmental disorders. 2019 Sep 5:1-4.  PMID: 31489540

Antoinette Sabatino DiCriscio, Yirui Hu, Vanessa Troiani. Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children. Journal of Autism and Developmental Disorders. 2019 Apr 29:1-5.  PMID: 31037428

Flannick J, Marcader JM, Fuchsberge C …. Kirchner HL, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature, 2019: 570(7759):71-76.  PMCID: PMC6699738

Thomas J Ferro, Agnes S Sundaresan ... Wendy Y Cheng. Clinical Burden of Asynchrony in Patients With Asthma When Using Metered-Dose Inhalers for Control. Allergy Asthma Proc. 2019;40(1):21-31. Epub 2018/12/26. DOI: 10.2500/aap.2019.40.4192.  PMID: 30582492

Tullika Garg, Ali Antar, Jennifer M Taylor. Urologic Oncology Workforce Diversity: A First Step in Reducing Cancer Disparities. Urol Oncol, Epub ahead of print, May 2019.  PMID 31104976.

Tullika Garg, Amanda J Young ... Terrence E Murphy. Reply to Association Between Treatment of Superficial Bladder Cancer and 10-year Mortality in Older Adults With Multiple Chronic Conditions. Cancer, vol 125, 652-653, February 2019.  PMID 30516841

Georgieva MV, Wheeler SB, Erim D, Smith-Bindman R, Loo R, Ng C, Garg T, Raynor M, Nielsen ME. Comparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria. JAMA Intern Med, Epub ahead of print, July 2019.  PMID 31355874

Gondalia R, Baldassari A, Holliday KM, Justice AE, Méndez-Giráldez R, Stewart JD, Liao D, Yanosky JD, Brennan KJM, Engel SM, Jordahl KM, Kennedy E, Ward-Caviness CK, Wolf K, Waldenberger M, Cyrys J, Peters A, Bhatti P, Horvath S, Assimes TL, Pankow JS, Demerath EW, Guan W, Fornage M, Bressler J, North KE, Conneely KN, Li Y, Hou L, Baccarelli AA, Whitsel EA. Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation. Environ Int. 2019 Jun 14;:104723. DOI: 10.1016/j.envint.2019.03.071. [Epub ahead of print].  PMID: 31208937

Gordon SC, Trudeau S, Li J, Zhou Y, Rupp LB, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Daida YG, Schmidt MA, Lu M; CHeCS investigators. Race, Age, and Geography Impact Hepatitis C Genotype Distribution in the United States. J Clin Gastroenterol. 2019 Jan;53(1):40-50. DOI: 10.1097/MCG.0000000000000872. PubMed PMID: 28737649.  PMCID: PMC5776051.

Grams ME, Sang Y, Ballew SH, Matsushita K, Astor BC, Carrero JJ, Chang AR, Inker LA, Kenealy T, Kovesdy CP, Lee BJ, Levin A, Naimark D, Pena MJ, Schold JD, Shalev V, Wetzels JFM, Woodward M, Gansevoort RT, Levey AS, Coresh J. Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data. J Am Soc Nephrol. 2019 Jul 10. pii: ASN.2019010008. DOI: 10.1681/ASN.2019010008. [Epub ahead of print].  PMCID: PMC6727262

Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, H Lester Kirchner, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.. Circulation. 2019 Jun 20.  PMCID: PMC6602806

Jing Hao, Rebecca Critchley-Thorne, David L Diehl, and Susan R Snyder. A Cost-Effectiveness Analysis Of An Adenocarcinoma Risk Prediction Multi-Biomarker Assay For Patients With Barrett’s Esophagus. ClinicoEconomics and Outcomes Research. 2019;11:623-35.   PMCID: PMC6818671

Hao J, Hassen D, Hao Q, Graham J, Paglia MJ, Brown J, et al. Maternal and infant health care costs related to preeclampsia. Obstetrics & Gynecology: November 04, 2019 Volume [Publish Ahead of Print] DOI: 10.1097/AOG.0000000000003581.  PMID: 31698380

Eveline A.M. Heijnsdijk, Daan Nieboer, Tullika Garg, Iris Lansdorp‐Vogelaar, Harry J. de Koning, and Matthew E. Nielsen. Cost-effectiveness of surveillance schedules in older adults with non-muscle-invasive bladder cancer. BJU Int, vol 123, 307-312, February 2019.  PMCID: PMC6378589

Stuart N. Hoffman, Thomas G. Urosevich, H. Lester. Kirchner, Joseph J. Boscarino, Ryan J. Dugan, Carrie A. Withey, Richard E. Adams, Charles R. Figley, and Joseph A. Boscarino*. Grapheme-Color Synethesia is Associated with PTSD among Deployed Veterans: Conformation of Previous Findings and Need for Additional Research. J Emergency Mental Health, 2019; 21(1).  PMCID: PMC6613655

Hou R, Wei J, Hu Y, Zhang X, Sun X, Chandrasekar EK, Voruganti VS. Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Cancer Causes and Control. 2019 Jun 5:1-2.  PMID: 31165965

Yirui Hu, PhD, Anastasia Yian Liu, BSc, Li Zhang, MD, PhD, Xianren Wu, MD, Shuai Shi, MSc, James R. Elmore, MD, Xiaopeng Zhang, MD, PhD.  A systematic review and meta-analysis of bivalirudin application in peripheral endovascular procedures. Journal of Vascular Surgery (provisionally accept, 2018 Oct.)  DOI: 10.1016/j.jvs.2018.12.037

Iqbal U, Khara H, Hu Y, Khan MA, Ovalle A, Siddique O, Sun H, Shellenberger MJ. Emergent versus urgent ERCP in acute cholangitis: a systematic review and meta-analysis. Gastrointestinal Endoscopy. 2019 Oct 16.  PMID: 31628955

Ishigami J, Padula WV, Grams ME, Chang AR, Jaar B, Gansevoort RT, Bridges JFP, Kovesdy CP, Uchida S, Coresh J, Matsushita K. Cost-effectiveness of Pneumococcal Vaccination Among Patients With CKD in the United States. Am J Kidney Dis. 2019 Mar 19. pii: S0272-6386(19)30132-5. DOI: 10.1053/j.ajkd.2019.01.025. [Epub ahead of print].  PMID: 30898360.

Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, et al. PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION. Nat Genet. 2019. DOI:10.1038/s41588-018-0334-2. Epub 2019 Feb 18.  PMCID: PMC6560635.

Justice AE, Chittoor G, Blanco E, Graff M, Wang Y, Albala C, Santos JL, Angel B, Lozoff B, Voruganti VS, North KE, Gahagan S. Genetic determinants of BMI from early childhood to adolescence: The Santiago Longitudinal Study (SLS). Pediatr Obes.  2019 Mar;14(3):e12479. DOI: 10.1111/ijpo.12479. Epub 2018 Dec 4.   PMCID: PMC6696926

Kadambi S, Soto-Perez-de-Celis E, Garg T, Battisti NML, Loh KP, Krok-Schoen JL, Moffat TG, Gil-Jr LA, Hsu T. Social support for older adults with cancer: Young International Society of Geriatric Oncology Review Paper. Accepted to Journal of Geriatric Oncology for Dr. Arti Hurria special issue.  PMID: 31628066

Mike Kersten, Cathy R. Cox, Erin A. Van Enkevort & Robert B. Arrowood. (2019). The Influence of Money-related Metaphors on Financial Anxiety and Spending. Metaphor and Symbol, 34, 229-242.  DOI: 10.1080/10926488.2019.1683957

Brown ES, Khaleghi N, Van Enkevort E, Ivleva E, Nakamura A, Holmes T, Mason BL, Escalante C. (2019). A pilot study of brexpiprazole for bipolar depression. Journal of Affective Disorders, 249, 315-318.  PMID: 30802696

Aldi T. Kraja, Chunyu Liu, Jessica L. Fetterman,  Mariaelisa Graff,  Christian Theil Have,  Charles Gu, …, Anne E. Justice, et al. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 Jan 3;104(1):112-138. DOI: 10.1016/j.ajhg.2018.12.001. Epub 2018 Dec 27.  PMCID: PMC6323610.

Jordan R. Kuiper, MS, Annemarie G. Hirsch, PhD, MPH, Karen Bandeen-Roche, PhD, Agnes S. Sundaresan, MD, MPH, Bruce K. Tan, MD, Robert C. Kern, MD, Robert P. Schleimer, PhD, and Brian S. Schwartz, MD, MS. Workplace indirect cost impacts of nasal and sinus symptoms and related conditions. J Occup Environ Med. 2019 Jun 13.  PMCID: PMC6766754

Julia Leddy, Jamie A. Green, Christina Yule, Juliann Molecavage, Josef Coresh, and Alex R. Chang. Improving proteinuria screening with mailed smartphone urinalysis testing in previously unscreened patients with hypertension: a randomized controlled trial. BMC Nephrol. 2019 Apr 18;20(1):132. DOI: 10.1186/s12882-019-1324-z.  PMCID: PMC6471866.

Leo M, McMullen CK, O’Keeffe-Rosetti M, Weinmann S, Garg T, Nielsen ME. External validation of the EORTC and NCCN bladder cancer recurrence and progression risk calculators in a U.S. community-based health system. Accepted to Urologic Oncology: Seminars and Investigations.  PMID: 31711836

Li J, Gordon SC, Rupp LB, Zhang T, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida YG, Lu M; CHeCS Investigators. Sustained virological response does not improve long-term glycaemic control in patients with type 2 diabetes and chronic hepatitis C. Liver Int. 2019 Jun;39(6):1027-1032. DOI: 10.1111/liv.14031. Epub 2019 Jan 24. PubMed PMID: 30570808.  PMCID: PMC6628708

Li J, Gordon SC, Rupp LB, Zhang T, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida YG, Lu M; CHeCS Investigators. Sustained virological response to hepatitis C treatment decreases the incidence of complications associated with type 2 diabetes. Aliment Pharmacol Ther. 2019 Mar;49(5):599-608. DOI: 10.1111/apt.15102. Epub 2019 Jan 16. PubMed PMID: 30650468.  PMCID: PMC6599612

Lu M, Wu KH, Li J, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Daida YG, Schmidt MA, Rupp LB, Zhang T, Trudeau S, Gordon SC. Adjuvant ribavirin and longer direct-acting antiviral treatment duration improve sustained virological response among hepatitis C patients at risk of treatment failure. J Viral Hepat. 2019 Oct;26(10):1210-1217. DOI: 10.1111/jvh.13162. Epub 2019 Jul 4. PubMed PMID: 31197910.  PMCID: PMC6764853

Mei Lu, Yueren Zhou, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu H Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Jia Li, Loralee B Rupp, Sheri Trudeau, Stuart C Gordon; Chronic Hepatitis Cohort Study Investigators. Trends in Diagnosed Chronic Hepatitis B in a US Health System Population, 2006-2015. Open Forum Infect Dis. 2019 Jun 14;6(7):ofz286. DOI: 10.1093/ofid/ofz286. eCollection 2019 Jul. PubMed PMID: 31341929.  PMCID: PMC6641786

Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, Hänninen IK, Tanaka T, de Jonge EAL, Kiefte-de Jong JC, Absher DM, Aslibekyan S, de Rijke YB, Fornage M, Hernandez DG, Hurme MA, Ikram MA, Jacques PF, Justice AE, …, Heil SG. Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. Am J Clin Nutr. 2019 Jun 5;. DOI: 10.1093/ajcn/nqz031. [Epub ahead of print].  PMCID: PMC666913

Merino J, Guasch-Ferré M, Ellervik C, Dashti HS, Sharp SJ, Wu P, Overvad K, Sarnowski C, Kuokkanen M, Lemaitre RN, Justice AE, et al. Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis. Accepted at The BMJ.  PMCID: PMC6652797

Shaffer R. S. Mok, David L. Diehl, Amitpal S. Johal, Harshit S. Khara, Bradley D. Confer, Prashant R. Mudireddy, Alicia H. Kovach, Mia M. Diehl, H. Lester Kirchner, and Zong-Ming E. Chen. Endoscopic ultrasound-guided biopsy in chronic liver disease: a randomized comparison of 19-G FNA and 22-G FNB needles. Endoscopy International Open, 2019; 7(1):E62-E71.  PMCID: PMC6327728

Moon KA, Pollak J, Poulsen MN, Hirsch AG, DeWalle J, Heaney CD, Aucott JN, Schwartz BS. Peridomestic and community-wide landscape risk factors for Lyme disease across a range of community contexts in Pennsylvania. Environmental Research, 2019; 178:108649. DOI: 10.1016/j.envres.2019.108649.  PMID: 31465993

Nguyen DM, Yassa MA, Tustison NJ, Roberts JM, Kulikova A, Nakamura A, Ivleva EI, Van Enkevort E, Brown ES. (2019). The Relationship Between Cumulative Exogenous Corticosteroid Exposure and Volumes of Hippocampal Subfields and Surrounding Structures. Journal of Clinical Psychopharmacology, 39, 653-657. DOI:10.1097/JCP.0000000000001120.  PMCID: PMC6856429

North CS, Van Enkevort E, Hong BA, Surís AM (2019). Association of PTSD symptom groups with functional impairment and distress in trauma-exposed disaster survivors. Psychological Medicine.  PMID: 31258106

Novick TK, Surapaneni A, Shin JI, Alexander GC, Inker LA, Wright EA, Chang AR, Grams ME. Associations of Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated GFR. Clin J Am Soc Nephrol. 2019 Oct 3.  PMCID: PMC6832057

Prashant Patel, MD, MS, Yirui Hu, PhD, Amy Kolinovsky, MS, Zhi Geng, MS, Jeffrey Ruhl, MS, Sarath Krishnamurthy, MS, Caroline deRichemond, CRNP, Ayesha Khan, MD, H. Lester Kirchner, PhD, Raghu Metpally, PhD, Laney K. Jones, PharmD, MPH, Amy C. Sturm, MS, David Carey, PhD, Susan Snyder, PhD, Marc S. Williams, MD, and Vishal C. Mehra, MD, PhD. Hidden Burden of Electronic Health Record-Identified Familial Hypercholesterolemia: Clinical Outcomes and Cost of Medical Care. J Am Heart Assoc. 2019; 8(13):e011822.  PMCID: PMC6662375

Poulsen MN, Bailey-Davis L, Pollak J, Hirsch AG, Schwartz BS. Household Food Insecurity and Home Food Availability in Relation to Youth Diet, Body Mass Index, and Adiposity. Journal of the Academy of Nutrition and Dietetics, 2019; 119(10):1666-1675. DOI: 10.1016/j.jand.2019.01.001.  PMCID: PMC6732246

Poulsen MN, Glass TA, Pollak J, Bandeen-Roche K, Hirsch AG, Bailey-Davis L, Schwartz BS. Associations of multidimensional socioeconomic and built environment factors with body mass index trajectories among youth in geographically heterogeneous communities. Preventive Medicine Reports. 2019; 15: 100939.  PMCID: PMC6637223

Qiao Y, Shin JI, Sang Y, Inker LA, Secora A, Luo S, Coresh J, Alexander GC, Jackson JW, Chang AR, Grams ME. Discontinuation of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Chronic Kidney Disease. Mayo Clin Proc. 2019 Oct 13. PMID: 31619367.  PMCID: PMC6858794

Henry Roberts, Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing*, Sameh W. Boktor, Conceptualization, Data curation, Methodology, Validation, Writing – review & editing, Kirsten Waller, Conceptualization, Methodology, Zahra S. Daar, Methodology, Writing – review & editing, Joseph A. Boscarino, Methodology, Writing – review & editing, Perry H. Dubin, Conceptualization, Anil Suryaprasad, Conceptualization, Methodology, Writing – original draft and Anne C. Moorman, Conceptualization, Methodology, Writing – original draft, Writing – review & editing. Underreporting of Hepatitis B and C virus infections - Pennsylvania, 2001-2015. PLoS One. 2019 Jun 6;14(6):e0217455. DOI: 10.1371/journal.pone.0217455. eCollection 2019.  PMCID: PMC6553716

Sadhu M1, Nicholson TF, Garcia R, Lampley S, Rain M, Fritz A, Jalalizadeh B, Van Enkevort E, Palka J, Brown ES. (2019). Relationship between trust in neighbors and regional brain volumes in a population-based study. Psychiatry Research: Neuroimaging, 286, 11-17.  PMID: 30852253

Sadhu M, Jalaizadeh B, Fritz A, Nicholson T, Garcia R, Lampley S, Rain M, Van Enkevort E, Brown ES (2019). Trust in physicians and regional brain volumes: A population-based study. The Primary Care Companion, 21(5).  PMID: 31644839

Shin JI, Grams ME, Coresh J, Chang AR, Matsushita K. Proteinuria and Risk of Lower-Extremity Amputation in Patients With Peripheral Artery Disease. Diabetes Care. 2019 Jul 15. pii: dc190764. DOI: 10.2337/dc19-0764. [Epub ahead of print].  PMCID: PMC6702610

Southern JB*, Higgins AM*, Young AJ, Kost KA*, Schreiter BR, Clifton M, Fulmer BR, Garg T. Letter to the Editor RE: Meller, Editorial Comment on: Risk factors for postoperative fever and systemic inflammatory response syndrome after ureteroscopy for stone disease. J Endourol, vol 33, 525-526, July 2019.  PMID 31233338

Southern JB*, Higgins AM*, Young AJ, Kost KA*, Schreiter BR, Clifton M, Fulmer BR, Garg T. Risk Factors for Postoperative Fever and Systemic Inflammatory Response Syndrome After Ureteroscopy for Stone Disease. J Endourol, vol33, 516-522, July 2019.  PMID 30569755.

Thomas NA, Van Enkevort E, Garret RK, Camp ME. (2019). Geriatric Psychiatry Inpatient Primer for Residents. Academic Psychiatry.   PMID: 31187436

Veenstra DL, Guzauskas G, Peterson J, Hassen DA, Snyder S, Hao J, Williams M. Cost-effectiveness of population genomic screening. Genet Med. 2019 Jul 15. DOI: 10.1038/s41436-019-0580-4. [Epub ahead of print.  PMID: 31303645

Wojcik GL, Graff M, Nishimura KK, Tao R, Haessler J, Gignoux CR, Highland HM, Patel YM, Sorokin EP, Avery CL, Belbin GM, Bien SA, Cheng I, Cullina S, Hodonsky CJ, Hu Y, Huckins LM, Jeff J, Justice AE, …, Buyske S, Haiman CA, Kooperberg C, Le Marchand L, Loos RJF, Matise TC, North KE, Peters U, Kenny EE, Carlson CS. Genetic analyses of diverse populations improves discovery for complex traits. Nature. 2019 Jun;570(7762):514-518. DOI: 10.1038/s41586-019-1310-4. Epub 2019 Jun 19.  PMCID: PMC6785182

Craig Wood, Lisa Bailey-Davis, Jacob Mowery, Christopher Seiler, Adam Cook, Krystal Cunningham, Allison Naylor, Scott Jamieson, David Rolston, and Christopher Still. Communicating Personalized Diabetes Risk with Options for Weight Management: Recruitment, Enrollment, and Outcomes. Abstracts from the 25th annual Health Care Systems Research Network. J Patient Cent Res Rev, 2019. 6(1):52-126.  PMCID: PMC6690399

Yanfei Zhang†, Waleed Zafar†, Dustin N. Hartzel, Marc S. Williams, Adrienne Tin, Alex R. Chang*† and Ming Ta Michael Lee*†. GSTM1 Copy Number Is Not Associated With Risk of Kidney Failure in a Large Cohort. Front Genet. 2019 Aug 30;10:765. DOI: 10.3389/fgene.2019.00765. eCollection 2019.   PMCID: PMC6728412

Zonozi R, Wu A, Shin JI, Secora A, Coresh J, Inker LA, Chang AR, Grams ME. Elevated Vancomycin Trough Levels in a Tertiary Health System: Frequency, Risk Factors, and Prognosis. Mayo Clin Proc. 2019 Jan;94(1):17-26.  PMCID: PMC6341482

Samad MD, Ulloa A, Wehner GJ, Jing L, Hartzel D, Good CW, Williams BA, Haggerty CM, Fornwalt BK.  Predicting Survival From Large Echocardiography and Electronic Health Record Datasets: Optimization With Machine Learning. J Am Coll Cardiol Img 2019; 12: 681-689.   PMCID: PMC6286869

Hicham Skali, Marcelo F. Di Carli, Ron Blankstein, Benjamin J. Chow, Rob S. Beanlands, Daniel S. Berman, Guido Germano, James K. Min, Michael Merhige, Brent Williams, Emir Veledar, Leslee J. Shaw, Sharmila Dorbala. Stress Myocardial Perfusion PET Provides Incremental Risk Prediction in Patients with and Patients without Diabetes.  Radiology: Cardiothoracic Imaging 2019; 1: e180018.  DOI: 10.1148/ryct.2019180018

 

Publications 2018

Winston E. Abara, Anne C. Moorman, Yuna Zhong, Melissa G. Collier, Lora B. Rupp, Stuart C. Gordon, Joseph A. Boscarino, Mark A. Schmidt, Connie Mah Trinacty, Scott D. Holmberg. The Predictive Value of International Classification of Disease Codes for Chronic Hepatitis C Virus Infection Surveillance: The Utility and Limitations of Electronic Health Records. Population Health Management. Apr 2018; 21: 110-15.  DOI: 10.1089/pop.2017.0004

Jonathan Auerbach, Richard Howey, Lai Jiang, Anne Justice, Liming Li, Karim Oualkacha, Sergi Sayols-Baixeras, and Stella W. Aslibekyan. Causal modeling in a multi-omics setting: insights from GAW20. BMC Genetics. 2018, 19 (Suppl 1) :74. doi: 0.1186/s12863-018-0645-4. Epub 2018 Sep 17.  PMCID: PMC6157026

Bailey-Davis L, Kling SMR, Cochran WJ, Hassink S, Hess L, Franceschelli-Hosterman J, Lutcher S, Marini M, Mowery J, Paul IM, Savage JS. Integrating and coordinating care between the Women, Infants, and Children Program and pediatricians to improve patient-centered preventive care for healthy growth. Transl Behav Med. 2018 Dec; 8(6): 944-952.  PMID: 29370433.

Benjamin EJ, Virani SS, Callaway CW, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O'Flaherty M, Palaniappan LP, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018 Mar 20;137(12):e67-e492. doi: 10.1161/CIR.0000000000000558. Epub 2018 Jan 31. Review. Erratum in: Circulation. 2018 Mar 20;137(12 ):e493.  PMID: 29386200

Joseph A. Boscarino, PhD, MPH, Richard E. Adams, PhD, Thomas G. Urosevich, OD, Stuart N. Hoffman, DO, H. Lester Kirchner, PhD, Joseph J. Boscarino, MA, Carrie A. Withey, BSN, Ryan J. Dugan, MS, and Charles R. Figley, PhD. Mental Health Impact of Homecoming Experience Among 1730 Formerly Deployed Veterans From the Vietnam War to Current Conflicts: Results From the Veterans' Health Study. J Nerv Ment Dis. 2018 Oct;206(10):757-764. doi: 10.1097/NMD.0000000000000879.  PMCID: PMC6171364.

Joseph A Boscarino, Carrie A Withey, Ryan J Dugan, and Thomas Alfieri. Evaluation of US Food and Drug Administration-recommended abuse-potential questions in chronic pain patients without history of recreational opioid use: results and plan for research. J Pain Res. 2018 Dec 17;12:9-15. doi: 10.2147/JPR.S176950. eCollection 2019. PubMed PMID: 30588075.  PMCID: PMC6301309.

Adam H Buchanan, MS, MPH,  Kandamurugu Manickam, MD, MPH,  Michelle N Meyer, PhD, JD, Jennifer K Wagner, JD, PhD, Miranda L G Hallquist, MSc, Janet L Williams, MS, Alanna Kulchak Rahm, PhD, MS, Marc S Williams, MD, Zong-Ming E Chen, MD, PhD, Chaitali K Shah, MD, Tullika K Garg, MD, MPH, Amanda L Lazzeri, BS, Marci L B Schwartz, ScM, D'Andra M Lindbuchler, MSN, Audrey L Fan, MS, Rosemary Leeming, MD, MHCM, Pedro O Servano, III, MD, Ashlee L Smith, DO, Victor G Vogel, MD, MHS, Noura S Abul-Husn, MD, PhD, Frederick E Dewey, MD, Matthew S Lebo, PhD, Heather M Mason-Suares, PhD, Marylyn D Ritchie, PhD, F Daniel Davis, PhD, David J Carey, PhD, David T Feinberg, MD, MBA, W Andrew Faucett, MS, David H Ledbetter, PhD, and Michael F Murray, MD. Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants. Genet Med, vol 20, 554-558, April 2018.   PMCID: PMC5930270

Bulbin D, Denio AE, Berger A, Brown J, Maynard C, Sharma T, Kirchner HL, Ayoub WT. Improved Gout Outcomes in Primary Care Using a Novel Disease Management Program: A Pilot Study. Arthritis Care and Research, 2018, 70(11):1679-1685.  PMID: 29438607

Joan A. Casey, PhD, Jonathan Pollak, MPP, M. Maria Glymour, ScD, Elizabeth R. Mayeda, PhD, Annemarie G. Hirsch, PhD, and Brian S. Schwartz, MD. Measures of SES for Electronic Health Record-based Research. American Journal of Preventive Medicine 2018, 54: 430-439.  PMCID: PMC5818301

Joan A. Casey, Holly C. Wilcox, Annemarie G. Hirsch, Jonathan Pollak, and Brian S. Schwartz. Associations of unconventional natural gas development with depression symptoms and disordered sleep in Pennsylvania. Scientific Reports 2018; 8:11375.  PMCID: PMC6063969

Cauley KA, Hu Y, Och J, Yorks PJ, Fielden SW. Modeling Early Postnatal Brain Growth and Development with CT: Changes in the Brain Radiodensity Histogram Birth to 2 years. American Journal of Neuroradiology. 2018 Feb 14.   PMID: 29449277

Alex R Chang, MD, MS, Aditya Surapaneni, PHD, H. Lester Kirchner, PHD, Amanda Young, MS, Holly J Kramer, MD, MPH, David J Carey, PhD, Lawrence J Appel, MD, MPH, and Morgan E Grams, MD, PHD. Metabolically Healthy Obesity and Risk of Kidney Function Decline. Obesity (Silver Spring). 2018 Apr;26(4):762-768. doi: 10.1002/oby.22134. Epub 2018 Mar 2.  PMCID: PMC5866209

Alex R Chang, MD, MS, Waleed Zafar, MBBS, MPH, and Morgan E. Grams, MD, PHD. Kidney Function in Obesity-Challenges in Indexing and Estimation. Adv Chronic Kidney Dis. 2018 Jan;25(1):31-40. doi:10.1053/j.ackd.2017.10.007. Review.  PMCID: PMC5836495.

Matthew Cole, Karen Bandeen-Roche, Annemarie G. Hirsch, Jordan Kuiper, Agnes S. Sundaresan, Bruce K. Tan, Robert P. Schleimer, Robert C. Kern, and Brian S. Schwartz. Longitudinal evaluation of clustering of chronic sinonasal and related symptoms using exploratory factor analysis. Allergy 2018; 73: 1715-1723.  PMCID: PMC6151861

Bradley H. Crotty, MD, MPH, Melissa Anselmo, MPH, Deserae Clarke, MPA, Joann G. Elmore, MD, Linda M. Famiglio, MD, Alan Fossa, MPH, Lydia Flier, MD, Jamie Green, MD, Jared W. Klein, MD, MPH, Suzanne Leveille, RN, PhD, Chen-Tan Lin, MD, Corey Lyon, DO, Roanne Mejilla, MPH, Matthew Moles, MD, Rebecca A. Stametz, DEd, MPH, Michelle Thompson, MD, Jan Walker, RN, MBA, Sigall K. Bell, MD. Open Notes in Teaching Clinics: A Multisite Survey of Residents to Identify Anticipated Attitudes and Guidance for Programs. J Grad Med Educ. 2018 Jun;10(3):292-300.  PMCID: PMC6008043

Antoinette Sabatino DiCriscio, Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing, Yirui Hu, Data curation, Formal analysis, Visualization, Writing – review & editing, and Vanessa Troiani, Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing. Task-induced pupil response and visual perception:. PloS one. 2018 Dec.  PMCID: PMC6306195

David L. Diehl, Shaffer R. S. Mok, Harshit S. Khara, Amitpal S. Johal, H. Lester Kirchner, and Fan Lin. Heparin priming of EUS-FNA needles does not adversely affect tissue cytology or immunohistochemical staining. Endoscopy International Open, 2018; 6(3):E356.  PMCID: PMC5842078

Marie Evans, Morgan E. Grams, Yingying Sang, Brad C. Astor, Peter J. Blankestijn, Nigel J. Brunskill, John F. Collins, Philip A. Kalra, Csaba P. Kovesdy, Adeera Levin, Patrick B. Mark, Olivier Moranne, Panduranga Rao, Pablo G. Rios, Markus P. Schneider, Varda Shalev, Haitao Zhang, Alex R. Chang, Ron T. Gansevoort, Kunihiro Matsushita, Luxia Zhang, Kai-Uwe Eckardt, Brenda Hemmelgarn, and David C. Wheeler. Risk Factors for Prognosis in Patients With Severely Decreased GFR. Kidney Int Rep. 2018 Jan 11;3(3):625-637. doi: 10.1016/j.ekir.2018.01.002. eCollection 2018 May.  PMCID: PMC5976849

Lindsay Fernández-Rhodes, Annie Green Howard, Mariaelisa Graff, Carmen R. Isasi, Heather M. Highland, Kristin L. Young, Esteban Parra, Jennifer E. Below, Qibin Qi, Robert C. Kaplan, Anne E. Justice, George Papanicolaou, Cathy C. Laurie, Struan F. A. Grant, Christopher Haiman, Ruth J. F. Loos, and Kari E. North.  Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018 Oct 2;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018.  PMCID: PMC6167893

Lindsay Fernández-Rhodes, Annie Green Howard, Ran Tao, Kristin L. Young, Mariaelisa Graff, Allison E. Aiello, Kari E. North, and Anne E. Justice. Characterization of the contribution of shared environmental and genetic factors to metabolic syndrome methylation heritability and familial correlations. BMC Genetics. 2018, 19 (Suppl 1):69. doi: 10.1186/s12863-018-0634-7. Epub 2018 Sep 17.  PMCID: PMC6157030

Tullika Garg, Kathryn Anzuoni, Valentina Landyn, Alexandra Hajduk, Stephen Waring, Leah R. Hanson, and Heather E. Whitson. The AGING Initiative experience: a call for sustained support for team science networks. Health Res Policy and Syst, vol 16, 41, May 2018.  PMCID: PMC5960077

Tullika Garg, Jill Nault Connors, Ilene G. Ladd, Tyler L. Bogaczyk, and Sharon L. Larson. Defining Priorities to Improve Patient Experience in Non-Muscle Invasive Bladder Cancer.  Bladder Cancer, vol 4, 121-128, January 2018.  PMID 29430512.

Garg T, Young AJ, Kost KA, Danella JF, Larson S, Nielsen ME, Kirchner HL. Burden of Multiple Chronic Conditions among Patients with Urological Cancer. J Urol, vol 199, 543-550, February 2018.  PMID 28789948

Garg T, Young AJ, O’Keeffe-Rosetti M, McMullen CK, Nielsen ME, Kirchner HL, Murphy TE. Association between treatment of superficial bladder cancer and 10-year mortality in older adults with multiple chronic conditions. Cancer vol 124, 4477-4485, December 2018.  PMID 30289971

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1789-1858.  PMCID: PMC6227754

Jason C. George, Waleed Zafar, Ion Dan Bucaloiu, and Alex R. Chang. Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia. Clin J Am Soc Nephrol. 2018 Jul 6;13(7):984-992. doi: 10.2215/CJN.13061117. Epub 2018 Jun 5.  PMCID: PMC6032596

Jamie A. Green, Patti L. Ephraim, Felicia F. Hill-Briggs, Teri Browne, Tara S. Strigo, et al. Putting Patients at the Center of Kidney Care Transitions: PREPARE NOW, a Cluster Randomized Controlled Trial. Contemporary Clinical Trials. 2018 Oct;73:98-110. Epub 2018 Sep 12.  PMCID: PMC6679594

Viktoria Gusarova, Colm O’Dushlaine, Tanya M. Teslovich, Peter N. Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V. Van Hout, Michael F. Murray, Anubha Mahajan, Jonas B. Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F. Gudbjartsson, Marketa Sjögren, Connor A. Emdin, Robert A. Scott, Wen-Jane Lee, Aeron Small, Lydia C. Kwee, Om Prakash Dwivedi, Rashmi B. Prasad, Shannon Bruse, Alexander E. Lopez, John Penn, Anthony Marcketta, Joseph B. Leader, Christopher D. Still, H. Lester Kirchner, Uyenlinh L. Mirshahi, Amr H. Wardeh, et al. Genetic Inactivation of ANGPLT4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications, 2018, 9(1):2252.  PMCID: PMC5997992

Seonggyun Han, Conceptualization, Data curation, Formal analysis, Writing – original draft, Dongwook Kim, Data curation, Formal analysis, Writing – original draft, Manu Shivakumar, Formal analysis, Young-Ji Lee, Writing – original draft, Tullika Garg, Data curation, Formal analysis, Writing – original draft, Jason E. Miller, Writing – review & editing, Ju Han Kim, Conceptualization, Dokyoon Kim, Conceptualization, Writing – original draft, Writing – review & editing, and Younghee Lee, Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing.  The effects of alternative splicing on miRNA binding sites in bladder cancer. PLoS One, vol 13, e0190718, January 2018.  PMCID: PMC5754136

Kasondra Hartman, Jinghong Li, and Tullika Garg. Clear cell adenocarcinoma of the female urethra: a case report. Urol Case Rep, vol 19, May 2018.  PMCID: PMC5991334

Lindsey Haynes-Maslowa, Isabel Osborne, Stephanie Jilcott Pitts, Marilyn Sitaker, Carmen Byker-Shanks, Lucia Leone, Adriana Maldonado, Jared McGuirt, Lauri Andress, Lisa Bailey-Davis, Barbara Baquero, Jane Kolodinsky, Brian Lo, Emily Morgan, Rebecca Senguin, Alice Ammerman. Rural corner store owners’ perceptions of stocking healthier foods in response to proposed SNAP retailer rule changes. Food Policy. 2018 Dec 1;81:58-66.  DOI: 10.1016/j.foodpol.2018.10.004

Haynes-Maslow L, Andress L, Pitts S, Osborne I, Baquero B, Bailey-Davis L, Byker-Shanks C, Houhtaling B, Kolodinsky J, Lo B, Morgan EH. Arguments Used in Public Comments to Support or Oppose the US Department of Agriculture’s Minimum Stocking Requirements: A Content Analysis. J Acad Nutr Diet. 2018 Sep;118(9):1664-1672.  PMID: 29452977

Annemarie G. Hirsch, T. Elizabeth Durden, Cara Nordberg, Andrea Berger, and Brian S. Schwartz. Associations of Four Community Factors With Longitudinal Change in Hemoglobin A1c Levels in Patients With Type 2 Diabetes. Diabetes Care 2018; 41(3): 461-468.  PMCID: PMC5864143

Annemarie G Hirsch, Rachel J Herman, Alison Rebman, Katherine A Moon, John Aucott, Christopher Heaney, and Brian S Schwartz. Obstacles to diagnosis and treatment of Lyme disease in the U.S.: A qualitative study. BMJ open 2018; 8: e021367.  PMCID: PMC6009554

Yirui Hu, DR Hoover. Simple Power and Sample Size Estimation for Non-Randomized Longitudinal Difference in Differences Studies. Journal of Biometrics & Biostatistics. 2018 Nov.  PMCID: PMC6663085

Yirui Hu, Donald R Hoover. Power Estimation in Planning Randomized Two-Arm Pre-Post Intervention Trials with Repeated Longitudinal Outcomes. Journal of Biometrics & Biostatistics. 2018 Aug.  PMCID:  PMC6207205

Yirui Hu, Formal analysis, Methodology, Writing – original draft, Writing – review & editing, Xinbei Yang, Data curation, Methodology, Writing – original draft, Writing – review & editing, Li Zhang, Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing, Xianren Wu, Conceptualization, Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing, Anastasia Yian Liu, Data curation, Validation, Writing – review & editing, Joseph A. Boscarino, Investigation, Writing – original draft, Writing – review & editing, H. Lester Kirchner, Funding acquisition, Writing – original draft, Writing – review & editing, Alfred S. Casale, Investigation, Validation, Writing – original draft, Writing – review & editing, and Xiaopeng Zhang, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing. Perioperative diltiazem or nitroglycerin in on-pump coronary artery bypass: A systematic review and network meta-analysis. PloS one. 2018 Aug 30;13(8):e0203315.  PMCID: PMC6117025

Anne E. Justice, Annie Green Howard, Lindsay Fernández-Rhodes, Misa Graff, Ran Tao, and Kari E. North. Direct and indirect genetic effects on triglycerides through Omics and correlated phenotypes. BMC Proceedings. 2018, 12 (Suppl 9):22. doi: 10.1186/s12919-018-0118-9. Epub 2018 Sep 17.  PMCID: PMC6157130

Kethireddy S, Bilgili B, Sees A, Kirchner HL, Ofoma UR, Light RB, Mirzanejad Y, Maki D, Kumar A, Layon AJ, Parrillo JE. Kumar A, Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Culture-Negative Septic Shock Compared to Culture-Positive Septic Shock: A Retrospective Cohort Study. Crit Care Med, 2018; 46(4): 506-512.  PMID: 29293143

Prakash Kharel, Deekchha Uprety, Abhinav B. Chandra, Yirui Hu, Anuradha Avinash Belur, and Ajay Dhakal. Bortezomib-Induced Pulmonary Toxicity: A Case Report and Review of Literature. Case Reports in Medicine. Volume 2018, Article ID 2913124.  PMCID: PMC6286773

Rachel L. Kininger, Sean M. O’Dell, Brandon K. Schultz (2018). The Feasibility and Effectiveness of School-Based Modular Therapy: A Systematic Literature Review. School Mental Health.  DOI: 10.1007/s12310-018-9270-7

Kirsten Koehler, J. Hugh Ellis, Joan A. Casey, David Manthos, Karen Bandeen-Roche, Rutherford Platt, and Brian S. Schwartz. Exposure Assessment Using Secondary Data Sources in Unconventional Natural Gas Development and Health Studies. Environ Sci Technol 2018; 15: 6061-9.  PMCID: PMC6437780

Jordan R. Kuiper, MS, Annemarie G. Hirsch, PhD, MPH, Karen Bandeen-Roche, PhD, Agnes S. Sundaresan, MD, MPH, Bruce K. Tan, MD, Robert P. Schleimer, PhD, Robert C. Kern, MD, Walter F. Stewart, PhD, MPH, and Brian S. Schwartz, MD, MS. Prevalence, severity, and risk factors for acute exacerbations of nasal and sinus symptoms by chronic rhinosinusitis status. Allergy. 2018. Epub 2018/01/14. doi: 10.1111/all.13409.  PMCID: PMC5993580

Benjamin Lazarus, MBBS, MPH, Aozhou Wu, MHS, Jung-Im Shin, MD, PhD, Yingying Sang, MS, G. Caleb Alexander, MD, MS, Alex Secora, MPH, Lesley A. Inker, MD, MS, Josef Coresh, MD, PhD, Alex R. Chang, MD, MS, and Morgan E. Grams, MD, PhD. Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study. JAMA Intern Med. 2018 Jul 1;178(7):903-910.  PMCID: PMC6145716

Michelle R. Lent Ph.D., Yirui Hu Ph.D., Peter N. Benotti M.D., Anthony T. Petrick M.D., G. Craig Wood M.S., Christopher D. Still D.O. and H. Lester Kirchner Ph.D.. Demographic, clinical, and behavioral determinants of 7-year weight change trajectories in Roux-en-Y gastric bypass patients. Surgery for Obesity and Related Diseases, 2018; 14(11):1680-1685.  DOI: 10.1016/j.soard.2018.07.023

J. Li, T. Zhang, S. C. Gordon, L. B. Rupp, S. Trudeau, S. D. Holmberg, A. C. Moorman, P. R. Spradling, E. H. Teshale, J. A. Boscarino, M. A. Schmidt, Y. G. Daida, M. Lu,; CHeCS Investigators. Impact of sustained virologic response on risk of type 2 diabetes among hepatitis C patients in the United States. J Viral Hepat. 2018 Aug;25(8):952-958. doi: 10.1111/jvh.12887. Epub 2018 Mar 15. PubMed PMID: 29478263.  PMCID: PMC6205163.

Zhongyuan Li ; Ye Ouyang ; Le Su ; Wei Jiang ; Yirui Hu ; Zhenyi Lin. Detecting Traffic Anomaly in Wireless Networks, An Analytics Methodology. 2018 Wireless Telecommunications Symposium.  DOI: 10.1109/WTS.2018.8363936

Lu M, Li J, Haller IV, Romanelli RJ, VanWormer JJ, Rodriguez CV, Raebel MA, Boscarino JA, Schmidt MA, Daida YG, Sahota A, Vincent J, Bowlus CL, Lindor K, Rupp LB, Gordon SC; FOLD Investigators. Factors Associated With Prevalence and Treatment of Primary Biliary Cholangitis in United States Health Systems. Clin Gastroenterol Hepatol. 2018 Aug;16(8):1333-1341.e6. doi: 10.1016/j.cgh.2017.10.018. Epub 2017 Oct 21.  PMID: 29066370

Mei Lu, PhD, Jia Li, PhD, Loralee B. Rupp, MS, MBA, Yueren Zhou, MS, Scott D. Holmberg, MD, MPH, Anne C. Moorman, MPH, RN, Philip R. Spradling, MD, Eyasu H. Teshale, MD, Joseph A. Boscarino, PhD, MPH, Yihe G. Daida, PhD, Mark A. Schmidt, PhD, MPH, Sheri Trudeau, MPH, and Stuart C. Gordon, MD. Changing trends in complications of chronic hepatitis C. Liver Int. 2018 Feb;38(2):239-247. doi: 10.1111/liv.13501. Epub 2017 Jul 21.  PMCID: PMC5777910

Lu M, Zhou Y, Haller IV, Romanelli RJ, VanWormer JJ, Rodriguez CV, Anderson H, Boscarino JA, Schmidt MA, Daida YG, Sahota A, Vincent J, Bowlus CL, Lindor K, Zhang T, Trudeau S, Li J, Rupp LB, Gordon SC; Fibrotic Liver Disease Consortium Investigators. Increasing Prevalence of Primary Biliary Cholangitis and Reduced Mortality with Treatment. Clin Gastroenterol Hepatol. 2018 Aug;16(8):1342-1350.e1. doi: 10.1016/j.cgh.2017.12.033. Epub 2017 Dec 23.  PMID: 29277621

Daniel D Maeng, Jove Graham, Michael Bogart, Jing Hao, and Eric A Wright. Impact of a pharmacist-led diabetes management on outcomes, utilization, and cost. Clinicoecon Outcomes Res. 2018 Sep 24;10:551-562. doi: 10.2147/CEOR.S174595. eCollection 2018. PubMed PMID: 30288070.  PMCID: PMC6161711

Anubha Mahajan,1 Jennifer Wessel, Sara M Willems, Wei Zhao,4 Neil R Robertson, Audrey Y Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, N William Rayner, Xiuqing Guo, Yingchang Lu, Man Li, Richard A Jensen, Yao Hu, Shaofeng Huo, Kurt K Lohman, Weihua Zhang, James P Cook, Bram Peter Prins, Jason Flannick, Niels Grarup, Vassily Vladimirovich Trubetskoy, Jasmina Kravic, Young Jin Kim, Denis V Rybin, Hanieh Yaghootkar, Martina Müller-Nurasyid, Karina Meidtner, Ruifang Li-Gao, Tibor V Varga, Jonathan Marten, Jin Li, Albert Vernon Smith, Ping An, Symen Ligthart, Stefan Gustafsson, Giovanni Malerba, Ayse Demirkan, Juan Fernandez Tajes, Valgerdur Steinthorsdottir, Matthias Wuttke, Cécile Lecoeur, Michael Preuss, Lawrence F Bielak, Marielisa Graff, Heather M Highland, Anne E Justice, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Gen. 2018 Apr;50(4):559-571. doi: 10.1038/s41588-018-0084-1. Epub 2018 Apr 9.  PMCID: PMC5898373

Mandalakas AM, Highsmith HY, Harris NM, Pawlicka A, Kirchner HL. T-SPOT.TB Performance in Routine Pediatric Practice in a Low Burden Setting. PIDJ, 2018; 37(4): 292-297.  PMID: 29140933

Kandamurugu Manickam, MD, MPH, Adam H. Buchanan, MS, MPH, Marci L. B. Schwartz, ScM, Miranda L. G. Hallquist, MSc, Janet L. Williams, MS, Alanna Kulchak Rahm, PhD, MS, Heather Rocha, MS, Juliann M. Savatt, MS, Alyson E. Evans, BS, Loren M. Butry, MS, Amanda L. Lazzeri, BS, D’Andra M. Lindbuchler, MSN, Carroll N. Flansburg, MPH, Rosemary Leeming, MD, MHCM, Victor G. Vogel, MD, MHS, Matthew S. Lebo, PhD, Heather M. Mason-Suares, PhD, Derick C. Hoskinson, PhD, Noura S. Abul-Husn, MD, PhD, Frederick E. Dewey, MD, John D. Overton, PhD, Jeffrey G. Reid, PhD, Aris Baras, MD, Huntington F. Willard, PhD, Cara Z. McCormick, MPH, Sarath B. Krishnamurthy, PhD, Dustin N. Hartzel, BS, Korey A. Kost, BS, Daniel R. Lavage, BS, Amy C. Sturm, MS, Lauren R. Frisbie, BS, T. Nate Person, MS, Raghu P. Metpally, PhD, Monica A. Giovanni, MS, Lacy E. Lowry, MD, Joseph B. Leader, BA, Marylyn D. Ritchie, PhD, David J. Carey, PhD, Anne E. Justice, PhD, H. Lester Kirchner, PhD, W. Andrew Faucett, MS, Marc S. Williams, MD, David H. Ledbetter, PhD, and Michael F. Murray, MD. Exome Sequencing-Based Screening for BRGCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants. JAMA Network Open, 2018; 1(5)e182140.  PMCID: PMC6324494

Jordi Merino, Hassan S. Dashti, Sherly X. Li, Chloé Sarnowski, Anne E. Justice, Misa Graff, et al. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. doi: 10.1038/s41380-018-0079-4. Epub 2018 Jul 9.  PMCID: PMC6326896

Mok SRS, Diehl DL, Johal AS, Khara HS, Confer BD, Mudireddy PR, Kirchner HL, Chen ZE. A prospective pilot comparison of wet and dry heparinized suction for EUS-guided liver biopsy (with videos). Gastrointest Endosc., 2018; 88(6):919-925.  PMID: 30120956

Moon KA, Pollack J, Hirsch AG, Aucott JN, Nordberg C, Heaney CD, Schwartz BS. Epidemiology of Lyme disease in Pennsylvania 2006-2014 using electronic health records. Tick & Tick-Borne Diseases. 2018. Advance online publication.  PMID: 30420251

Anne C. Moorman, BSN, MPH, Loralee B. Rupp, MSE, Stuart C. Gordon, MD, Yuna Zhong, MSPH, Jian Xing, PhD, Mei Lu, PhD, Joseph A. Boscarino, PhD, MPH, Mark A. Schmidt, PhD, Yihe G. Daida, PhD, Eyasu H. Teshale, MD, Philip R. Spradling, MD, Scott D. Holmberg, MD, MPH; CHeCS Investigators. Long-Term Liver Disease, Treatment, and Mortality Outcomes Among 17,000 Persons Diagnosed with Chronic Hepatitis C Virus Infection: Current Chronic Hepatitis Cohort Study Status and Review of Findings. Infect Dis Clin North Am. 2018 Jun;32(2):253-268. doi: 10.1016/j.idc.2018.02.002. Review.  PMCID: PMC6211170

ANNE C. MOORMAN, JIAN XING, NOELE P. NELSON; CHeCS Investigators. Need for Increasing Hepatitis A Virus Vaccination Among Patients Infected With Hepatitis B Virus and Hepatitis C Virus. Gastroenterology. 2018 Jun;154(8):2015-2017. doi: 10.1053/j.gastro.2018.04.031. Epub 2018 May 3.  PMCID: PMC6252091

ANNE C. MOORMAN, MPH JIAN XING, PhD, LORALEE B. RUPP, MS, MBA, STUART C. GORDON, MD, PHILIP R. SPRADLING, MD, JOSEPH A. BOSCARINO, PhD, MARK A. SCHMIDT, MPH, PhD, YIHE G. DAIDA, PhD, EYASU H. TESHALE, MD, and SCOTT D. HOLMBERG, MD, MPH; Chronic Hepatitis Cohort Study Investigators. Hepatitis B Virus Infection and Hepatitis C Virus Treatment in a Large Cohort of Hepatitis C-Infected Patients in the United States. Gastroenterology. 2018 Feb;154(3):754-758. doi: 10.1053/j.gastro.2017.12.002. Epub 2018 Jan 19.  PMCID: PMC5850951

Tessa K. Novick, Aditya Surapaneni, Jung-Im Shin, Shoshana H. Ballew, G. Caleb Alexander, Lesley A. Inker, Alex R. Chang, and Morgan E. Grams. Prevalence of Opioid, Gabapentinoid, and NSAID Use in Patients with CKD. Clin J Am Soc Nephrol. 2018 Dec 7;13(12):1886-1888.  PMCID: PMC6302317

Uchenna R. Ofoma, MD, MS, Suresh Basnet, MD, Andrea Berger, MAS, H. Lester Kirchner, PhD, and Saket Girotra, MD, SM. Trends in Survival for In-Hospital Cardiac Arrests During Nights and Weekends. J Am Coll Cardiol, 2018; 71(4): 402-411.  PMCID: PMC5858924

Melissa N. Poulsen  Lisa Bailey‐Davis  Joseph DeWalle  Jacob Mowery  Brian S. Schwartz. Agricultural Implications of Unconventional Natural Gas Development: Divergent Perceptions of Sustainable and Conventional Farmers. Culture, Agriculture, Food and Environment. 2018 Jun;40(1):24-35.  DOI: 10.1111/cuag.12104

Melissa N. Poulsen, PhD,MPH, Emily A. Knapp, MHS, Annemarie G. Hirsch, PhD, MPH, Lisa Bailey-Davis, DEd, RD, Jonathan Pollak, MPP, and Brian S. Schwartz, MD, MS. Comparing objective measures of the built environment in their associations with youth physical activity and sedentary behavior across heterogeneous geographies. Health and Place 2018; 49: 30-38.  PMCID: PMC5807108

Poulsen MN, Pollak J, Sills DL, Casey JA, Nachman KE, Cosgrove SE, Stewart D, Schwartz BS. High-density poultry operations and community-acquired pneumonia in Pennsylvania. Environ Epidemiol 2018; 2: e013, 1-7.  DOI: 10.1097/EE9.0000000000000013

Melissa N. Poulsen, PhD, MPH, Jonathan Pollak, MPP, Deborah L. Sills, PhD, Joan A. Casey, PhD, Sara G. Rasmussen, PhD, MHS, Keeve E. Nachman, PhD, MHS, Sara E. Cosgrove, MD, MS, Dalton Stewart, and Brian S. Schwartz, MD, MS. Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. Int J Hyg Environ Health 2018; 221: 323-33.  PMCID: PMC5880295

Alanna Kulchak Rahm, Deborah Cragun, Jessica Ezzell Hunter, Mara M. Epstein, Jan Lowery, Christine Y. Lu, Pamala A. Pawloski, Ravi N. Sharaf, Su-Ying Liang, Andrea N. Burnett-Hartman, James M. Gudgeon, Jing Hao, Susan Snyder, Radhika Gogoi, Ilene Ladd, and Marc S. Williams. Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts. BMC Health Serv Res. 2018 Oct 30;18(1):824.  PMCID: PMC6208012.

Noorbakhsh-Sabet N, Tsivgoulis G, Shahjouei S, Hu Y, Goyal N, Alexandrov AV, Zand R. Racial Difference in Cerebral Microbleed Burden Among a Patient Population in the Mid-South United States. Journal of Stroke and Cerebrovascular Diseases. 2018 Jun 23.  PMID: 29945767

Jennifer S. Savage, Samantha M. R. Kling, Adam Cook, Lindsey Hess, Shawnee Lutcher, Michele Marini, Jacob Mowery, Shannon Hayward, Sandra Hassink, Jennifer Franceschelli Hosterman, Ian M. Paul, Chris Seiler, and Lisa Bailey-Davis. A patient-centered, coordinated care approach delivered by community and pediatric primary care providers to promote responsive parenting: pragmatic randomized clinical trial rationale and protocol. BMC Pediatrics. 2018 Dec;18(1):293.  PMCID: PMC6123992

Schell JO, Cohen RA, Green JA, Rubio D, Childers JW, Claxton R, Jeong K, Arnold RM. NephroTalk: Evaluation of a Palliative Care Communication Curriculum for Nephrology Fellows. J Pain Symptom Manage. 2018 Nov;56(5):767-773.e2. Epub 2018 Aug 14.  PMID: 30118758

Sharma A, Moon J, Bailey-Davis L. Loss Aversion of Time: Serving School Lunches Faster without Impacting Meal Experience. Ecology of Food and Nutrition. 2018, 57(6):456-472. PMID:30421976

Jung-Im Shin, Alex Secora, G. Caleb Alexander, Lesley A. Inker, Josef Coresh, Alex R. Chang, and Morgan E. Grams.  Risks and Benefits of Direct Oral Anticoagulants across the Spectrum of GFR among Incident and Prevalent Patients with Atrial Fibrillation. Clin J Am Soc Nephrol. 2018 Aug 7;13(8):1144-1152. doi: 10.2215/CJN.13811217. Epub 2018 Jul 12.  PMCID: PMC6086708

Snyder SR, Hao J, Cavallari LH, Geng Z, Elsey A, Johnson JA, Mohamed Z, Chaiyakunapruk N, Chong HY, Dahlui M, Shabaruddin FH, Patrinos GP, Mitropoulou C, Williams MS. Generic Cost-Effectiveness Models: A Proof of Concept of a Tool for Informed Decision-Making for Public Health Precision Medicine. Public Health Genomics. 2018;21(5-6):217-227. doi: 10.1159/000500725. Epub 2019 Jun 12.  PMCID: PMC6762029.

Philip R. Spradling, MD, Jian Xing, PhD, Loralee B. Rupp, MS, MBA, Anne C. Moorman, MPH, Stuart C. Gordon, MD, Mei Lu, PhD, Eyasu H. Teshale, MD, Joseph A. Boscarino, PhD, Mark A. Schmidt, PhD, Yihe G. Daida, PhD, Scott D. Holmberg, MD, MPH; Chronic Hepatitis Cohort Study (CHeCS) Investigators. Uptake of and Factors Associated With Direct-acting Antiviral Therapy Among Patients in the Chronic Hepatitis Cohort Study, 2014 to 2015. J Clin Gastroenterol. 2018 Aug;52(7):641-647. doi: 10.1097/MCG.0000000000000857.  PMCID: PMC6427915.

Jeffrey Staples, Evan K. Maxwell, Nehal Gosalia, Claudia Gonzaga-Jauregui, Christopher Snyder, Alicia Hawes, John Penn, Ricardo Ulloa, Xiaodong Bai, Alexander E. Lopez, Cristopher V. Van Hout, Colm O’Dushlaine, Tanya M. Teslovich, Shane E. McCarthy, Suganthi Balasubramanian, H. Lester Kirchner, Joseph B. Leader, Michael F. Murray, et al. Profiling and Leveraging Relatedness In a Precision Medicine Cohort of 92,455 Exomes. Am J Hum Genet, 2018, 102(5):874-889.  PMCID: PMC5986700

Agnes S. Sundaresan, Gargi Schneider, Joy Reynolds, and H. Lester Kirchner. Identifying Asthma Exacerbation-Related Emergency Department Visit Using Electronic Medical Record and Claims Data. Appl Clin Inform. 2018;9(3):528-40. Epub 2018/07/25. doi: 10.1055/s-0038-1666994.  PMCID: PMC6051766

Yun J. Sung, Thomas W. Winkler, Lisa de las Fuentes, Amy R. Bentley, Michael R. Brown, Aldi T. Kraja … Anne E. Justice, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 1;102(3):375-400. doi: 10.1016/j.ajhg.2018.01.015. Epub 2018 Feb 15.  PMCID: PMC5985266.

Valérie Turcot, Yingchang Lu, Heather M Highland, Claudia Schurmann, Anne E Justice, Rebecca S Fine, Jonathan P Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in underpinning obesity. Nature Genetics. 2018 Jan;50(1):26-41. Doi: 10.1038/s41588-017-0011-x.  PMCID: PMC5945951.

LTC. Thomas G Urosevich, MS, USA, (Ret.), Joseph J Boscarino, MA, Stuart N Hoffman, DO, H Lester Kirchner, PhD, Charles R Figley, PhD, Richard E Adams, PhD, Carrie A Withey, BSN, and Joseph A Boscarino, PhD, MPH. Visual Dysfunction and Associated Co-Morbidities as Predictors of Mild Traumatic Brain Injury Seen Among Veterans in non-VA Facilities: Implications for Clinical Practice. J Military Med, 2018; 183(11-12):e564-e570.  PMCID: PMC62662209

Wei J, Wang T, Wang T, Hu Y, etc. The association and dose-response relationship between dietary intake of α-linolenic acid and risk of CHD: a systematic review and meta-analysis of cohort studies. British Journal of Nutrition. 2018 Jan;119 (1), 83-89.  PMID: 29355094

G. Craig Wood, MS, Daniel Horwitz, MS, Christopher D. Still, DO, Tooraj Mirshahi, PhD, Peter Benotti, MD, Manish Parikh, MD, and Annemarie G. Hirsch, PhD. Performance of the DiaRem score for predicting diabetes remission in two health systems following bariatric surgery procedures in Hispanic and non-Hispanic white patients. Obesity Surgery 2018; 28: 61-68.  PMCID: PMC5736407

Mehreen Iqbal, Fatin T. Nahi, Yirui Hu, H. Lester Kirchner, Michael H. Entrup, Xiaopeng Zhang, Dietrich Gravenstein and Xianren Wu. Distinct effects of propofol and methohexital at titrated dosages on hemodynamics, stimulus energy, and seizure durations during electroconvulsive therapy. Curr Res Neurol Neurosurg. 2018 April.

Arasaratnam P, Sadreddini M, Yam Y, Kansal V, Dorbala S, Di Carli MF, Beanlands RS, Merhige ME, Williams BA, Veledar E, Min JK, Chen L, Ruddy TD, Germano G, Berman DS, Shaw LJ, Chow BJW.  Prognostic value of vasodilator response using rubidium-82 positron emission tomography myocardial perfusion imaging in patients with coronary artery disease. European Journal of Nuclear Medicine and Molecular Imaging 2018; 45: 538-548.  PMID: 29177706

Erthal F, Hossain A, Dorbala S, Shaw LJ, Di Carli MF, Merhige ME, Williams BA, Veledar E, Pencina MJ, Min JK, Berman DS, deKemp R, Beanlands RS, Chow B. Is There an Age When Myocardial Perfusion Imaging May No Longer Be Prognostically Useful? Circ Cardiovasc Imaging 2018; 11: e007322.  PMID: 30012824

Williams BA, Agarwal S. Applying the Seattle Heart Failure Model in the Office Setting in the Era of Electronic Medical Records. Circ J 2018; 82: 724-731.  PMID: 29343672

Williams BA, Chagin KM, Bash LD, Boden WE, Duval S, Fowkes FGR, Mahaffey KW, Patel MD, D’Agostino RB, Peterson ED, Kattan MW, Bhatt DL, Bonaca MP.  External validation of the TIMI risk score for secondary cardiovascular events among patients with recent myocardial infarction. Atherosclerosis 2018; 272: 80-86.  PMID: 29579671

Brent A Williams.  Focusing on the Problem, Not the Tool: Acknowledging Technology’s Limits. Biomed J Sci & Tech Res 2018; 11.  DOI: 10.26717/BJSTR.2018.09.001858

 

Department news

Recent Grants: 

Melissa Poulsen, PhD, MPH – National Institutes of Health K01 award, “Understanding the role of community determinants in opioid use disorder and program implementation factors influencing patient adherence to opioid agonist therapy,” awarded July 1, 2020

Geisinger receives $3.8 million in funding support to study childhood obesity. https://fox56.com/news/local/geisinger-receives-38-million-in-funding-support-to-study-childhood-obesity